The short answer
Review passionflower before using it with temazepam. The exact combination’s sedation risk is not established, and short studies of passionflower alone do not settle the question.
What this answer covers
Oral Passiflora incarnata aerial-part preparations, not another species or every extract.
- Supplement or preparation
- Passiflora incarnata
- Medication ingredient
- temazepam
Read both parts of the guidance
The passionflower monograph describes possible driving impairment and traditional sleep-aid use. It also lists no reported interactions. Neither statement proves a temazepam interaction.
Short trials provide limited reassurance
Two small perioperative studies did not find greater sedation or psychomotor impairment with their passionflower products. They did not test ongoing co-use with temazepam.
Check the actual sleep product
Bring its species, plant part and other ingredients. No validated spacing rule resolves the missing combination evidence.
Protect your alertness
Temazepam can impair coordination and alertness. Avoid driving when affected. Seek urgent help for severe difficulty waking or breathing, and tell the prescriber about all other sedating medicines and alcohol.
Evidence and practical considerations
Side effects & toxicity
A cautious product review is reasonable, but exact additive sedation remains insufficiently established.
- Exact scope
- Oral Passiflora incarnata aerial-part preparations, not another species or every extract. with Exact oral temazepam; no blanket benzodiazepine metabolic or route transfer.
- Medication form and route
- oral; other cannabis routes only if explicitly discussed
- Timing or duration
- Exact duration and dose depend on source; single-dose and chronic use are distinguished.
What remains uncertain
- Monograph lists no reported interactions; perioperative studies did not find added sedation with their preparations. No routine temazepam co-use study.
Factors that may matter: preparation and plant part; dose; other medicines; baseline alertness; clinical indication.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral temazepam.
CNS depression, impaired coordination and alertness can occur; concomitant CNS depressants require caution. Dependence and withdrawal risks require individualized tapering rather than abrupt cessation. Metabolized primarily through conjugation with no active metabolites; not an alprazolam CYP3A profile. Complex sleep behaviors can occur and CNS depressants may increase their risk.
How this applies: Exact RxNorm ingredient and oral formulation confirmed in original label; use exact indication and metabolic boundaries.
Does not quantify the requested botanical interaction risks, prove every herb is sedating, or establish a protective supplement interval.
Source 2: official guidance
ema.europa.eu · Source check Sep 10, 2026
Population: People considering the specified supplement.
Traditional sleep-aid use; may impair driving. Section 4.5 lists no reported interactions.
How this applies: Preparation-specific context; not a directly measured temazepam interaction.
Traditional-use monograph, not a temazepam trial. No reported interaction is not proof of safety.
Source 3: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults undergoing ambulatory surgery.
Anxiety decreased, but sedation and psychomotor recovery were similar between groups.
How this applies: Preparation-specific context; not a directly measured temazepam interaction.
Short perioperative exposure to one product, no temazepam; does not establish chronic combination safety.
Source 4: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults aged 25-55 undergoing spinal anesthesia.
No significant group differences in sedation, psychomotor function, hemodynamics or side effects.
How this applies: Preparation-specific context; not a directly measured temazepam interaction.
Selected perioperative population, no temazepam; not proof that all preparations lack impairment.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact claims adjudicated against captured originals and explicit comparator/co-use boundaries. | |
| Research summary published |
Article revision: ee85d0503f397f46
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.