The short answer
Review passionflower before adding it to trimipramine, particularly if alertness is already affected. Human studies of specific passionflower products did not consistently show sedation.
What this answer covers
Oral Passiflora incarnata herb; not fruit or other species.
- Supplement or preparation
- Passiflora incarnata
- Medication ingredient
- trimipramine
Assess your current alertness
Trimipramine may affect alertness. The passionflower monograph cautions about driving, making the product and your daily activities relevant.
Anxiety relief was not the same as sedation
Small perioperative trials found anxiety improvement without significant differences in sedation or psychomotor measures for their tested products.
Know what has not been tested
Those trials did not include trimipramine. The monograph lists no reported interactions, which is not a demonstration of safe co-use or a protective spacing rule.
Watch for impaired alertness
Trimipramine can affect alertness and coordination. Avoid driving if affected and contact the prescriber if added sleepiness, confusion or unsteadiness appears after a new product. Severe confusion, fainting or inability to wake needs urgent assessment.
Evidence and practical considerations
Side effects & toxicity
Conditional alertness review, with no measured exact-pair effect and negative standalone findings retained.
- Exact scope
- Oral Passiflora incarnata herb; not fruit or other species. with Exact oral trimipramine maleate capsules. RxNorm IN10834 / PIN71532 maleate; mesylate PIN236189 is distinct. Oral maleate capsules only.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact co-use trial; perioperative extracts cannot establish effects of all retail products.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed oral trimipramine.
Label describes a sedative component and explicitly names tryptophan and St John’s wort in serotonin warnings. Cardiovascular and anticholinergic precautions apply.
How this applies: RxNorm IN10834 / PIN71532 maleate; mesylate PIN236189 is distinct. Oral maleate capsules only.
No universal supplement interval, event rate or preparation equivalence established.
Source 2: official guidance
ema.europa.eu · Source check Sep 10, 2026
Population: People considering the specified supplement.
Traditional sleep-aid use; may impair driving. Section 4.5 lists no reported interactions.
How this applies: Preparation-specific original evidence; no untested antidepressant or route transfer.
Traditional-use monograph, not a trimipramine co-use trial. No reported interaction is not proof of safety.
Source 3: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults undergoing ambulatory surgery.
Anxiety decreased, but sedation and psychomotor recovery were similar between groups.
How this applies: Preparation-specific original evidence; no untested antidepressant or route transfer.
Short perioperative exposure to one product, without trimipramine.
Source 4: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults aged 25-55 undergoing spinal anesthesia.
No significant group differences in sedation, psychomotor function, hemodynamics or side effects.
How this applies: Preparation-specific original evidence; no untested antidepressant or route transfer.
Selected perioperative population, without trimipramine.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: db77815dd48c30d3
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.