The short answer
An interaction between St John’s wort and temazepam has not been established. Ask for a product-specific review; results with alprazolam cannot automatically be applied to temazepam.
What this answer covers
Oral Hypericum perforatum extract and oral temazepam; different benzodiazepine metabolic pathways remain distinct.
- Supplement or preparation
- Hypericum perforatum
- Medication ingredient
- temazepam
Why the medicine name matters
Temazepam is mainly processed by conjugation. The frequently cited St John’s wort study measured alprazolam, whose CYP3A metabolism differs. It is not a direct temazepam test.
Extracts are not interchangeable
Another study using a low-hyperforin St John’s wort product found little effect on alprazolam exposure. These preparation differences make broad predictions about all products unreliable.
A dosing gap is not established
Bring the herb’s exact extract and dose to the pharmacist. No validated interval shows that spacing St John’s wort from temazepam prevents an interaction.
Keep treatment changes supervised
Follow the prescribed temazepam plan. Do not take extra doses to counter a supplement, and do not stop regular treatment abruptly. Ask the prescriber to plan any medication or supplement changes.
Evidence and practical considerations
Absorption & effectiveness
Alprazolam CYP3A induction evidence does not establish temazepam loss of effect or a need for a fixed separation interval.
- Exact scope
- Oral Hypericum perforatum extract and oral temazepam; different benzodiazepine metabolic pathways remain distinct. with Exact oral temazepam; no blanket benzodiazepine metabolic or route transfer.
- Medication form and route
- oral; other cannabis routes only if explicitly discussed
- Timing or duration
- Exact duration and dose depend on source; single-dose and chronic use are distinguished.
What remains uncertain
- No exact temazepam human co-use study identified; temazepam is mainly conjugated, and extract hyperforin content affects other-drug findings.
Factors that may matter: preparation and plant part; dose; other medicines; baseline alertness; clinical indication.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral temazepam.
CNS depression, impaired coordination and alertness can occur; concomitant CNS depressants require caution. Dependence and withdrawal risks require individualized tapering rather than abrupt cessation. Metabolized primarily through conjugation with no active metabolites; not an alprazolam CYP3A profile. Complex sleep behaviors can occur and CNS depressants may increase their risk.
How this applies: Exact RxNorm ingredient and oral formulation confirmed in original label; use exact indication and metabolic boundaries.
Does not quantify the requested botanical interaction risks, prove every herb is sedating, or establish a protective supplement interval.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Twelve healthy volunteers in an open-label fixed-order crossover.
Alprazolam exposure fell about one-half and clearance increased; elimination half-life shortened.
How this applies: Apply only to exact medication, preparation and study exposure; comparator treatment is not co-use.
Single extract and short exposure, healthy volunteers; no anxiety-treatment failure endpoint. Does not imply reduced gut absorption or transfer to predominantly conjugated benzodiazepines.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Healthy participants in randomized placebo-controlled studies.
Changes in probe exposures were small and judged clinically irrelevant; hyperforin levels were below quantification.
How this applies: Apply only to exact medication, preparation and study exposure; comparator treatment is not co-use.
Preparation-specific result, not permission to assume all retail products are low-hyperforin or all doses safe.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact claims adjudicated against captured originals and explicit comparator/co-use boundaries. | |
| Research summary published |
Article revision: c177f8bc43e738eb
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.