The short answer
A chamomile-temazepam sedation interaction is theoretical rather than established. Review concentrated chamomile products and other sleep aids with your pharmacist.
What this answer covers
German chamomile, Matricaria chamomilla/re-cutita synonym, specified oral extract; not Roman chamomile or every tea/plant part.
- Supplement or preparation
- Matricaria chamomilla
- Medication ingredient
- temazepam
Separate theory from a measured interaction
NCCIH describes reasons to suspect chamomile might interact with sedatives, but does not present a tested temazepam combination. That uncertainty should remain visible.
The insomnia trial was inconclusive
A small trial of standardized German chamomile extract did not show significant improvement in its primary sleep measures or a difference in adverse events versus placebo. Temazepam co-use was not tested.
Confirm the species and preparation
German and Roman chamomile are different plants. Bring the extract or tea label and all added ingredients; the trial does not establish equivalence of these products or a safe separation interval.
Protect your alertness
Temazepam can impair coordination and alertness. Avoid driving when affected. Seek urgent help for severe difficulty waking or breathing, and tell the prescriber about all other sedating medicines and alcohol.
Evidence and practical considerations
Side effects & toxicity
Official guidance describes sedative interaction as theoretical; an insomnia extract trial found no significant primary sleep or adverse-event difference.
- Exact scope
- German chamomile, Matricaria chamomilla/re-cutita synonym, specified oral extract; not Roman chamomile or every tea/plant part. with Exact oral temazepam; no blanket benzodiazepine metabolic or route transfer.
- Medication form and route
- oral; other cannabis routes only if explicitly discussed
- Timing or duration
- Exact duration and dose depend on source; single-dose and chronic use are distinguished.
What remains uncertain
- No exact temazepam co-use trial. No preparation-independent sedation effect or spacing interval.
Factors that may matter: preparation and plant part; dose; other medicines; baseline alertness; clinical indication.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral temazepam.
CNS depression, impaired coordination and alertness can occur; concomitant CNS depressants require caution. Dependence and withdrawal risks require individualized tapering rather than abrupt cessation. Metabolized primarily through conjugation with no active metabolites; not an alprazolam CYP3A profile. Complex sleep behaviors can occur and CNS depressants may increase their risk.
How this applies: Exact RxNorm ingredient and oral formulation confirmed in original label; use exact indication and metabolic boundaries.
Does not quantify the requested botanical interaction risks, prove every herb is sedating, or establish a protective supplement interval.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Thirty-four adults with chronic primary insomnia.
No significant primary sleep outcome or adverse-event difference.
How this applies: Apply only to exact medication, preparation and study exposure; comparator treatment is not co-use.
No temazepam co-use. German chamomile botanical synonym is explicit; not Roman chamomile, every plant part or tea/extract equivalence.
Source 3: official botanical guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: Users of German or Roman chamomile, distinguished in source.
Sedative interactions are described as theoretical rather than proven.
How this applies: Supports uncertainty and product identification, not a blanket CNS-depression claim.
No exact temazepam combination trial. Species, plant part and extract matter.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact claims adjudicated against captured originals and explicit comparator/co-use boundaries. | |
| Research summary published |
Article revision: 5f7b02bf3645b98f
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.