The short answer
Review lemon balm before adding it to temazepam. Some preparations may affect alertness, but an exact combination study has not established the amount of added sedation.
What this answer covers
Oral Melissa officinalis leaf preparations; other parts and mixed products are not assumed equivalent.
- Supplement or preparation
- Melissa officinalis
- Medication ingredient
- temazepam
What the monograph says
Lemon balm guidance describes traditional use for mild stress and sleep, but states that interaction data are unavailable.
What human evidence adds
A small healthy-volunteer study found reduced alertness after one higher extract dose, while a lower dose improved some task performance. It did not include temazepam.
Identify the actual product
Check that the product contains the studied plant part and list any added herbs. A tea, concentrated extract and mixed sleep product may differ. No protective timing gap is established for lemon balm and temazepam.
Protect your alertness
Temazepam can impair coordination and alertness. Avoid driving when affected. Seek urgent help for severe difficulty waking or breathing, and tell the prescriber about all other sedating medicines and alcohol.
Evidence and practical considerations
Side effects & toxicity
Preparation-specific alertness caution is reasonable; the broad exact-pair sedation claim remains insufficient.
- Exact scope
- Oral Melissa officinalis leaf preparations; other parts and mixed products are not assumed equivalent. with Exact oral temazepam; no blanket benzodiazepine metabolic or route transfer.
- Medication form and route
- oral; other cannabis routes only if explicitly discussed
- Timing or duration
- Exact duration and dose depend on source; single-dose and chronic use are distinguished.
What remains uncertain
- No exact temazepam co-use trial; traditional sleep-aid use and separate-product studies do not prove additive CNS depression.
Factors that may matter: preparation and plant part; dose; other medicines; baseline alertness; clinical indication.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral temazepam.
CNS depression, impaired coordination and alertness can occur; concomitant CNS depressants require caution. Dependence and withdrawal risks require individualized tapering rather than abrupt cessation. Metabolized primarily through conjugation with no active metabolites; not an alprazolam CYP3A profile. Complex sleep behaviors can occur and CNS depressants may increase their risk.
How this applies: Exact RxNorm ingredient and oral formulation confirmed in original label; use exact indication and metabolic boundaries.
Does not quantify the requested botanical interaction risks, prove every herb is sedating, or establish a protective supplement interval.
Source 2: official herbal monograph
ema.europa.eu · Source check Sep 10, 2026
Population: Users of specified oral herbal preparations.
Traditional use for mild stress and aiding sleep; may impair driving. No interaction data available.
How this applies: Supports preparation-specific caution; does not establish additive sedation with the requested drug.
Traditional use is not proof of exact drug interaction. Part/extract boundaries and absence of clinical co-use data remain.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Eighteen healthy volunteers in a randomized double-blind crossover.
The 600 mg dose increased calmness and reduced alertness; 300 mg improved some task performance.
How this applies: Apply only to exact medication, preparation and study exposure; comparator treatment is not co-use.
Acute exact-extract study, no benzodiazepine co-use. Dose-dependent findings cannot establish all lemon-balm products cause sedation.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact claims adjudicated against captured originals and explicit comparator/co-use boundaries. | |
| Research summary published |
Article revision: 165cbef89dac338d
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.