The short answer
It is uncertain whether ginger root powder adds to bleeding risk from celecoxib. Small human studies give mixed platelet-test results and do not establish bleeding outcomes for this combination.
What this answer covers
Oral Zingiber officinale dried rhizome powder, often labeled ginger root powder. Extracts, essential oils, fresh food and mixed products are separate preparations.
- Supplement or preparation
- Zingiber Officinale (Ginger) Root Powder
- Medication ingredient
- celecoxib
What the studies can tell us
One study in eight healthy men found no effect after 2 g of dried ginger. Another reported no platelet change with 4 g daily for three months but reduced aggregation after a single 10 g dose. These laboratory findings do not define a safe dose or show an increased clinical bleeding rate with celecoxib.
Check the exact product
The current EMA ginger monograph covers specific rhizome preparations and lists no known medicine interactions. That wording does not prove this unstudied combination safe. Powder, concentrated extracts and fresh ginger cannot be assigned the same exposure simply because they share a plant name.
Review your bleeding risks
Celecoxib itself can cause serious stomach or intestinal bleeding. Tell your prescriber about previous ulcers or bleeding and about aspirin, anticoagulants, steroids and other pain medicines. Share all supplement labels. The available sources do not establish an hours-apart schedule that prevents this possible interaction.
When to get medical help
Stop celecoxib and seek medical help promptly for vomiting blood, black or bloody stools, or faintness with possible bleeding. Report new persistent stomach pain or unusual bleeding to your clinician. These warning signs matter even when the added effect of the supplement is uncertain.
Evidence and practical considerations
Side effects & toxicity
The inspected evidence is insufficient to establish that ginger root powder increases bleeding when combined with celecoxib.
- Exact scope
- Oral Zingiber officinale dried rhizome powder, often labeled ginger root powder. Extracts, essential oils, fresh food and mixed products are separate preparations. with Celecoxib, RxCUI 140587 IN, oral treatment.
- Medication form and route
- Oral
What remains uncertain
- No inspected clinical co-use study establishes this exact interaction or its frequency. Absence of such evidence does not prove safety.
Factors that may matter: Exact product and dose; Kidney function; Other medicines; Prior gastrointestinal bleeding or ulcers.
Read the supporting source summaries
Source 1: Regulatory prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral celecoxib.
Celecoxib can cause serious gastrointestinal bleeding. The label also warns of renal toxicity and hyperkalemia. Healthy-volunteer testing found no reduction of platelet aggregation or increase in bleeding time at the tested celecoxib regimens.
How this applies: Exact celecoxib identity, baseline risks and clinical counseling; no direct botanical co-use outcome.
Baseline adverse effects do not prove an added botanical interaction. NSAID wording must not be converted into an aspirin-like platelet effect for celecoxib.
Source 2: original human clinical study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Eight healthy male volunteers in a randomized blinded placebo comparison.
No detected difference in bleeding time, platelet count, thromboelastography or whole-blood platelet aggregation.
How this applies: Dried ginger human surrogate results, not direct celecoxib co-use or a safe dose threshold.
Eight healthy men and brief follow-up; original abstract only. Does not establish long-term effects, a safe dose or a celecoxib interaction.
Source 3: original human clinical study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Coronary artery disease participants in the ginger portions of a placebo-controlled study. Original abstract does not provide subgroup counts or aspirin co-medication details.
The repeated 4 g regimen did not change the measured platelet aggregation responses; the single 10 g exposure reduced aggregation. Clinical bleeding was not established.
How this applies: Exact-species powdered ginger with mixed platelet results; no inspected celecoxib coadministration.
Original abstract only; subgroup counts and concomitant medication details are not supplied. Platelet aggregation is not a clinical bleeding endpoint; no safe-use threshold is inferred.
Source 4: government herbal medicinal-product monograph
ema.europa.eu · Source check Sep 10, 2026
Population: Users of medicinal ginger preparations within the monograph, with indication- and age-specific restrictions.
Lists no known medicinal-product interactions for its defined preparations.
How this applies: Defines dried rhizome powder and tincture separately and places blanket bleeding claims in context.
No-known-interactions wording is not proof of safety or a controlled celecoxib-powder trial.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and article drafted. | |
| Research summary published |
Article revision: 4e647750539a7345
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.