The short answer
An added bleeding risk from garlic supplements with celecoxib has not been established in the inspected clinical evidence. Discuss the exact supplement before adding it, especially if you have ulcers or use other medicines that affect bleeding.
What this answer covers
Oral Allium sativum supplements. The inspected trial used odor-control tablets; culinary garlic, oils and other extracts are not interchangeable.
- Supplement or preparation
- Allium sativum
- Medication ingredient
- celecoxib
What the studies can tell us
A study of 62 healthy volunteers tested garlic tablets after a month-long aspirin washout. Garlic did not significantly change the platelet tests, but nosebleeds and heavier menstrual bleeding were reported. Participants were asked not to take NSAIDs during garlic use, so it was not a celecoxib combination study.
Check the exact product
The tested product supplied one, two or three 1250 mg odor-control tablets daily for a month. Those results cannot be assigned to an uncharacterized garlic extract or usual food portions. Bring the ingredient list and daily serving to your pharmacist.
Review your bleeding risks
Celecoxib itself can cause serious stomach or intestinal bleeding. Tell your prescriber about previous ulcers or bleeding and about aspirin, anticoagulants, steroids and other pain medicines. Share all supplement labels. The available sources do not establish an hours-apart schedule that prevents this possible interaction.
When to get medical help
Stop celecoxib and seek medical help promptly for vomiting blood, black or bloody stools, or faintness with possible bleeding. Report new persistent stomach pain or unusual bleeding to your clinician. These warning signs matter even when the added effect of the supplement is uncertain.
Evidence and practical considerations
Side effects & toxicity
The inspected evidence is insufficient to establish that garlic increases bleeding when combined with celecoxib.
- Exact scope
- Oral Allium sativum supplements. The inspected trial used odor-control tablets; culinary garlic, oils and other extracts are not interchangeable. with Celecoxib, RxCUI 140587 IN, oral treatment.
- Medication form and route
- Oral
What remains uncertain
- No inspected clinical co-use study establishes this exact interaction or its frequency. Absence of such evidence does not prove safety.
Factors that may matter: Exact product and dose; Kidney function; Other medicines; Prior gastrointestinal bleeding or ulcers.
Read the supporting source summaries
Source 1: Regulatory prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral celecoxib.
Celecoxib can cause serious gastrointestinal bleeding. The label also warns of renal toxicity and hyperkalemia. Healthy-volunteer testing found no reduction of platelet aggregation or increase in bleeding time at the tested celecoxib regimens.
How this applies: Exact celecoxib identity, baseline risks and clinical counseling; no direct botanical co-use outcome.
Baseline adverse effects do not prove an added botanical interaction. NSAID wording must not be converted into an aspirin-like platelet effect for celecoxib.
Source 2: primary randomized clinical comparison
pmc.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 62 healthy volunteers aged 20-50 years in an open-label study.
Aspirin inhibited arachidonic-acid-induced aggregation. Garlic did not significantly change the tested aggregation measures. Menstrual bleeding and nosebleeding were reported during garlic treatment despite the laboratory null result.
How this applies: Human garlic-tablet platelet results and symptom reports only. NSAIDs were excluded during garlic exposure, so this does not measure the celecoxib combination.
Aspirin and garlic were not coadministered. Open-label symptoms, unclear adverse-event denominators between abstract and body, and one commercial product limit inference; no pooled bleeding percentage is adopted.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and article drafted. | |
| Research summary published |
Article revision: 100dd0925942d34d
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.