The short answer
The inspected clinical evidence does not establish that Panax ginseng increases bleeding with celecoxib. This uncertainty is a reason to review the product and your other risks, rather than assume the combination is safe.
What this answer covers
Oral Panax ginseng. Panax quinquefolius and other species are excluded. Red, unprocessed and extracted products cannot be treated as equivalent without characterization.
- Supplement or preparation
- Panax ginseng
- Medication ingredient
- celecoxib
What the studies can tell us
A small study gave Panax ginseng with warfarin to 12 stroke patients and warfarin alone to 13 patients for two weeks. It found no significant difference in the measured clotting tests. Warfarin works differently from celecoxib, and these results do not answer whether ginseng adds to celecoxib-related stomach bleeding.
Check the exact product
Check that the label identifies Panax ginseng, its plant preparation and the daily amount. American ginseng is a different species. The inspected study abstract does not fully describe the ginseng extract, so it cannot validate another product or a safe dose.
Review your bleeding risks
Celecoxib itself can cause serious stomach or intestinal bleeding. Tell your prescriber about previous ulcers or bleeding and about aspirin, anticoagulants, steroids and other pain medicines. Share all supplement labels. The available sources do not establish an hours-apart schedule that prevents this possible interaction.
When to get medical help
Stop celecoxib and seek medical help promptly for vomiting blood, black or bloody stools, or faintness with possible bleeding. Report new persistent stomach pain or unusual bleeding to your clinician. These warning signs matter even when the added effect of the supplement is uncertain.
Evidence and practical considerations
Side effects & toxicity
The inspected evidence is insufficient to establish that Panax ginseng increases bleeding when combined with celecoxib.
- Exact scope
- Oral Panax ginseng. Panax quinquefolius and other species are excluded. Red, unprocessed and extracted products cannot be treated as equivalent without characterization. with Celecoxib, RxCUI 140587 IN, oral treatment.
- Medication form and route
- Oral
What remains uncertain
- No inspected clinical co-use study establishes this exact interaction or its frequency. Absence of such evidence does not prove safety.
Factors that may matter: Exact product and dose; Kidney function; Other medicines; Prior gastrointestinal bleeding or ulcers.
Read the supporting source summaries
Source 1: Regulatory prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral celecoxib.
Celecoxib can cause serious gastrointestinal bleeding. The label also warns of renal toxicity and hyperkalemia. Healthy-volunteer testing found no reduction of platelet aggregation or increase in bleeding time at the tested celecoxib regimens.
How this applies: Exact celecoxib identity, baseline risks and clinical counseling; no direct botanical co-use outcome.
Baseline adverse effects do not prove an added botanical interaction. NSAID wording must not be converted into an aspirin-like platelet effect for celecoxib.
Source 2: peer-reviewed original research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 25 newly diagnosed ischemic stroke patients, 12 assigned Panax ginseng plus warfarin and 13 warfarin alone.
No significant between-group difference in peak or area-under-curve PT and INR was found.
How this applies: Exact Panax ginseng identity but a different medicine and coagulation outcome. Warfarin PT/INR findings do not establish celecoxib-associated gastrointestinal bleeding or platelet effects.
Small open-label, short study of new warfarin users; abstract does not specify the full extract characterization. The original abstract reports 25, not the 35 repeated in some reviews.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and article drafted. | |
| Research summary published |
Article revision: e7fd508f794b93e5
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.