The short answer
Review passionflower before using it with clonazepam. The exact combination’s sedation risk has not been established.
What this answer covers
Oral Passiflora incarnata aerial-part preparations; other species and extracts are not equivalent.
- Supplement or preparation
- Passiflora incarnata
- Medication ingredient
- clonazepam
Read the full monograph
The passionflower monograph describes traditional sleep-aid use and possible driving impairment, while listing no reported interactions. That supports caution without proving a medication interaction.
Short trials do not show a universal sedative effect
Two small perioperative studies did not find increased sedation or psychomotor impairment with their passionflower preparations. They did not test ongoing use with this medicine.
Check the actual preparation
Bring the species, plant part, extract and other sleep ingredients for review. A fixed time gap has not been shown to settle the combination risk.
Watch for impaired alertness
Clonazepam can affect alertness and coordination. Avoid driving if affected. Seek urgent help for severe difficulty waking or breathing, and tell the prescriber about alcohol, opioids and all other sedating products.
Evidence and practical considerations
Side effects & toxicity
Traditional sleep-aid guidance supports product review, but it does not establish exact-pair additive CNS depression.
- Exact scope
- Oral Passiflora incarnata aerial-part preparations; other species and extracts are not equivalent. with Exact oral clonazepam tablets. CYP3A may participate in reduction and oxidation; named enzyme-inducing anticonvulsants lower levels. REM sleep behavior disorder is a separate, off-label study population, not the labeled panic/seizure indication.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- Monograph lists no reported interactions; small perioperative trials did not show added sedation with the tested products. No exact co-use evidence in these sources.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral clonazepam.
Can impair alertness and coordination; other CNS depressants can increase impairment. Opioid combinations have a specific respiratory-depression warning. Dependence and withdrawal require supervised changes. CYP3A may participate in reduction and oxidation; named enzyme-inducing anticonvulsants lower levels. REM sleep behavior disorder is a separate, off-label study population, not the labeled panic/seizure indication.
How this applies: Exact IN and labeled oral formulation; route, salt and metabolite distinctions retained.
No quantified risk for every herb or universal protective spacing interval. Opioid-specific evidence does not prove equal botanical respiratory risk.
Source 2: official guidance
ema.europa.eu · Source check Sep 10, 2026
Population: People considering the specified supplement.
Traditional sleep-aid use; may impair driving. Section 4.5 lists no reported interactions.
How this applies: Preparation-specific context; not a directly measured clonazepam interaction.
Traditional-use monograph, not a clonazepam trial. No reported interaction is not proof of safety.
Source 3: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults undergoing ambulatory surgery.
Anxiety decreased, but sedation and psychomotor recovery were similar between groups.
How this applies: Original named medication and preparation only; indirect evidence for clonazepam. Comparator arms are not coadministration.
Short perioperative exposure to one product, no clonazepam; does not establish chronic combination safety.
Source 4: randomized placebo-controlled trial
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 60 adults aged 25-55 undergoing spinal anesthesia.
No significant group differences in sedation, psychomotor function, hemodynamics or side effects.
How this applies: Original named medication and preparation only; indirect evidence for clonazepam. Comparator arms are not coadministration.
Selected perioperative population, no alprazolam; not proof that all preparations lack impairment.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: ac882c8dbab30b86
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.