The short answer
Identify this licorice-root product before combining it with trimipramine. Glycyrrhizic-acid-containing licorice can affect blood pressure and potassium, but the inventory name does not establish your product’s exposure.
What this answer covers
Radix et Rhizoma Glycyrrhizae: exact species, processed root and glycyrrhizic-acid content unresolved; deglycyrrhizinated products are distinct.
- Supplement or preparation
- Radix et Rhizoma Glycyrrhizae
- Medication ingredient
- trimipramine
Confirm the root and its contents
Ask for the Latin species, plant part, processing and glycyrrhizic-acid content. The EMA assessment covers specified Glycyrrhiza roots, not every product with a similar name.
Measured licorice exposure can affect pressure
A two-week trial of a quantified glycyrrhizic-acid intake raised home systolic blood pressure and suppressed renin and aldosterone. It did not include trimipramine.
Potassium is a separate concern
The assessment describes potassium loss with excess licorice exposure. Trimipramine has cardiovascular precautions, but that does not establish a measured combined arrhythmia rate.
Review rather than self-correct
Bring the product to the prescriber, especially with weakness, swelling or palpitations. Do not start potassium supplements or change trimipramine to compensate for an assumed licorice effect.
Evidence and practical considerations
Side effects & toxicity
Exact ambiguous-root combination risk remains insufficiently established; preparation-specific cardiovascular review is appropriate.
- Exact scope
- Radix et Rhizoma Glycyrrhizae: exact species, processed root and glycyrrhizic-acid content unresolved; deglycyrrhizinated products are distinct. with Exact oral trimipramine maleate capsules. RxNorm IN10834 / PIN71532 maleate; mesylate PIN236189 is distinct. Oral maleate capsules only.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact pair study or species/content confirmation; general licorice hazards cannot be assigned uniformly.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed oral trimipramine.
Label describes a sedative component and explicitly names tryptophan and St John’s wort in serotonin warnings. Cardiovascular and anticholinergic precautions apply.
How this applies: RxNorm IN10834 / PIN71532 maleate; mesylate PIN236189 is distinct. Oral maleate capsules only.
No universal supplement interval, event rate or preparation equivalence established.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Twenty-eight healthy adults in randomized crossover trial.
Home systolic pressure rose during licorice exposure; renin and aldosterone were suppressed.
How this applies: Only the named drug, preparation, route and measured endpoints apply.
No trimipramine, unspecified inventory-root species and no exact preparation match. Reported within-period changes must not be confused with a between-treatment effect size.
Source 3: official botanical assessment
ema.europa.eu · Source check Sep 10, 2026
Population: Users of specified Glycyrrhiza root preparations.
Excess exposure may cause hypertension, potassium loss and occasionally cardiac rhythm problems.
How this applies: Identity-limited supplement hazard context, not exact-pair proof.
Inventory name does not establish species or glycyrrhizic acid content. No trimipramine combination study.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: ebd9a248d7e11de5
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.