Find the available answers about clozapine and supplements. Each guide explains its evidence and the forms it covers.
28 published guides. Coverage is limited to the combinations listed.
Oral Glycyrrhiza glabra root products containing glycyrrhizin. This assessment does not treat deglycyrrhizinated licorice, topical preparations, other Glycyrrhiza species or licorice-flavored products as equivalent.
Read the interaction guide →Scutellaria lateriflora (American skullcap) oral preparations, specifically characterized aerial-part extracts where stated. Scutellaria baicalensis and isolated flavonoids are distinct.
Read the interaction guide →Valeriana officinalis root and rhizome preparations taken by mouth; blends and other valerian species are not equivalent.
Read the interaction guide →Oral chaparral products identified as Larrea tridentata. Evidence does not establish equivalent risks for other Larrea species, purified constituents or topical preparations.
Read the interaction guide →Orally ingested Hyoscyamus niger containing pharmacologically active antimuscarinic alkaloids; unknown-strength and highly diluted preparations require separate assessment.
Read the interaction guide →Applies to Hypericum perforatum, commonly called St. John's wort. Product strength varies, and the evidence does not define a safe preparation, dose, or washout interval.
Read the interaction guide →Oral Withania somnifera preparations; Sensoril trial findings cannot be extended to every root, leaf or mixed product.
Read the interaction guide →Oral Camellia Sinensis Leaf Extract that contains caffeine. Catechin or extract mass alone does not establish caffeine exposure. Coffea arabica seed extract is a separate botanical and is not assessed in this pair.
Read the interaction guide →Piper methysticum oral extracts and beverages; preparation, plant material and co-exposures vary.
Read the interaction guide →Oral Citrus aurantium supplements, with attention to extract composition, synephrine content and additional ingredients. Whole plant, isolated p-synephrine, juice and multi-ingredient products are not assumed interchangeable.
Read the interaction guide →Orally ingested Atropa belladonna containing pharmacologically active antimuscarinic alkaloids; unknown-strength and highly diluted preparations require separate assessment.
Read the interaction guide →Humulus lupulus hop-strobile preparations taken by mouth; beer, isolated constituents and valerian-hops blends are not interchangeable.
Read the interaction guide →Oral caffeine-containing Paullinia cupana seed preparations, including the var. sorbilis material in the final EMA assessment. Whole plant, other parts and caffeine-free formulations are not assigned seed-equivalent exposure.
Read the interaction guide →Caffeine from drinks, foods and supplements during oral clozapine treatment. The studies used different caffeine amounts and do not establish a daily limit that is safe for everyone.
Read the interaction guide →Oral Matricaria chamomilla (German chamomile) flower extract. Evidence from flowering-top extract is preparation-specific; Roman chamomile, tea and topical use are not equivalent.
Read the interaction guide →Oral caffeine-containing Cola acuminata seed preparations. Other Cola species, Garcinia kola, other plant parts and cola beverages cannot be assumed equivalent.
Read the interaction guide →Passiflora incarnata above-ground herb preparations; other Passiflora species, fruit products and multi-herb blends are separate exposures.
Read the interaction guide →Oral senna leaf/fruit laxative preparations or standardized sennosides; not all extracts are dose-equivalent.
Read the interaction guide →Medicinal oral whole or powdered Plantago afra seed used as a bulk-forming laxative. Other plant parts, extracts, food fibre and Plantago ovata husk are not treated as interchangeable.
Read the interaction guide →Products labeled charcoal or charcoal powder, without a specified activation process. The evidence concerns medical activated charcoal, mainly in poisoning care, and does not establish equivalent effects for every oral charcoal supplement.
Read the interaction guide →Oral melatonin with oral clozapine. The clearest official melatonin information concerns a 2 mg prolonged-release medicine; effects cannot be assumed identical across doses and formulations.
Read the interaction guide →Oral S-adenosylmethionine supplements; not methionine, endogenous SAM metabolism or injected formulations.
Read the interaction guide →Melissa officinalis oral extract; the acute study used a standardized product. Tea, essential oils, other species and blends are not assumed equivalent.
Read the interaction guide →Oral laxative-active Frangula purshiana bark preparations, including standardized cascara bark tea or extracts.
Read the interaction guide →The direct report concerns inhaled smoke from cannabis together with tobacco. Oral extracts, purified CBD, hemp seed products and noncombustion routes are not equivalent exposures.
Read the interaction guide →Oral caffeine-containing Ilex paraguariensis leaf preparations. Other Ilex species, non-leaf material and decaffeinated products are distinct. Roasted leaf is not equated with the non-roasted preparation covered by the HMPC monograph.
Read the interaction guide →Oral Mitragyna speciosa products. A single low-dose leaf tea study does not represent concentrated alkaloid products or prolonged use.
Read the interaction guide →Matricaria chamomilla species-level entry; oral tea, flowering-top extracts and other preparations are not interchangeable. Roman chamomile is a different botanical.
Read the interaction guide →A supplement missing from this list has not been cleared for use with the medication. These pages do not assess every product, formulation, or combination.
Publication status, clinical review and change history are shown in each interaction guide.