The short answer
High-dose green-tea extract has its own liver-enzyme safety signal, but added harm specifically with canagliflozin has not been established. Ordinary tea and concentrated extracts are different exposures.
What this answer covers
Camellia sinensis leaf extract; catechin amount, caffeine, extraction and dose matter.
- Supplement or preparation
- Camellia Sinensis Leaf Extract
- Medication ingredient
- canagliflozin
A concentrated extract produced a signal
A year-long trial of high-dose green-tea extract found more ALT elevations and nausea than placebo. Overall adverse-event and serious-event proportions did not significantly differ.
It was not a canagliflozin interaction trial
The result concerns the extract’s own safety. It cannot quantify additional toxicity caused by canagliflozin or demonstrate that the drug raises catechin exposure.
Do not infer the risk from the botanical name
The tested concentrated catechin exposure is different from a cup of tea or every leaf-extract capsule. Caffeine content also cannot be assumed from the name.
Review the product and symptoms
Discuss high-dose extract use and new symptoms with the clinician. Canagliflozin has separate volume-depletion precautions; these do not prove additive extract toxicity or establish a safe supplement dose.
Evidence and practical considerations
Side effects & toxicity
Intrinsic high-dose extract liver signal is not evidence of increased canagliflozin-pair toxicity; null overall-event findings and preparation limits retained.
- Exact scope
- Camellia sinensis leaf extract; catechin amount, caffeine, extraction and dose matter. with Oral canagliflozin RxCUI1373458 IN; agent-specific renal and metabolic mechanisms.
- Medication form and route
- oral medication; oral supplement
What remains uncertain
- No arbitrary interval, class-only metabolism assumption or unmeasured pair-event rate.
Factors that may matter: Preparation; Dose; Kidney function; Volume status; Other diabetes treatment.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral canagliflozin
SGLT2 inhibition increases urinary glucose. Volume contraction can cause hypotension or acute kidney injury, with risk modifiers. UGT inducers may lower drug exposure and effectiveness. Insulin/secretagogue co-use increases hypoglycemia risk.
How this applies: Exact single-ingredient canagliflozin, not all SGLT2 agents or combination products.
Warnings do not establish every botanical interaction or routine sodium supplementation. Renal function and whole regimen matter.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 1075postmenopausal women in a breast-risk trial.
High-dose extract increased ALT elevations and nausea, while total and serious adverse-event proportions did not significantly differ.
How this applies: Exact canagliflozin and supplement preparation/endpoint boundaries retained.
Not canagliflozin co-use; high-dose concentrated extract not ordinary tea or every leaf extract. Liver-enzyme events are not an exact-pair risk rate.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Prepared exact canagliflozin article separating volume effects, metabolic exposure and intrinsic supplement risks. | |
| Research summary published |
Article revision: dc3305b70675f6cb
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.