The short answer
Green tea extract has its own liver-safety concerns and needs review during bedaquiline treatment. No direct study established that this exact combination increases liver injury, but adding a potentially hepatotoxic product is a meaningful precaution.
What this answer covers
Camellia sinensis leaf extract supplements, especially sustained high-dose exposure; brewed tea and every extract are not equivalent.
- Supplement or preparation
- Camellia Sinensis Leaf Extract
- Medication ingredient
- bedaquiline
The medication already requires liver vigilance
SIRTURO labeling directs avoiding alcohol and other hepatotoxic drugs and monitoring liver tests during treatment. This medicine warning does not supply an injury rate for the supplement combination.
What the original supplement evidence shows
A large randomized high-dose extract study found more liver-enzyme abnormalities than placebo and recurrence after rechallenge. A smaller trial in fatty liver found improved enzymes with a different regimen. Population, product and dose differences matter; neither trial tested this medicine.
Separate intrinsic harm from a proven interaction
The sources support concern about the specified supplement exposure itself. They do not demonstrate synergistic injury, a safe combined dose or the same effect for every preparation. A biochemical change is not automatically liver failure.
Discuss the product before adding it
Show the TB clinician the exact product and dose. Follow the prescribed liver-monitoring plan and avoid unapproved potentially hepatotoxic products. Seek prompt medical advice for jaundice, dark urine, persistent nausea or unusual fatigue rather than trying a spacing interval.
Evidence and practical considerations
Side effects & toxicity
Conditional hepatic co-use precaution from exact medication warning and original preparation-specific supplement liver evidence. No exact-pair increased incidence or synergistic causality established; route/preparation limits and contrary findings retained.
- Exact scope
- Camellia sinensis leaf extract supplements, especially sustained high-dose exposure; brewed tea and every extract are not equivalent. with Bedaquiline fumarate oral SIRTURO tablets, strength expressed as bedaquiline.
- Medication form and route
- oral medication; oral supplement
What remains uncertain
- No unmeasured pair incidence, blanket class transfer or arbitrary spacing interval.
Factors that may matter: Preparation; Dose; Other medicines; Organ function.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 11, 2026
Population: People prescribed bedaquiline
QT prolongation; assess and correct low potassium/calcium/magnesium. Avoid other hepatotoxic exposures; monitor liver function. Avoid strong/moderate CYP3A4 inducers.
How this applies: Exact bedaquiline RxCUI 1364504 IN, with stated salt/formulation/route bridge.
Exact route and formulation apply. Label precautions do not quantify untested botanical pairs or support arbitrary supplement doses.
Source 2: Original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 11, 2026
Population: 1,021 women with normal baseline enzymes in analyzed randomized cohort.
More liver-enzyme abnormalities than placebo, with improvement after stopping and recurrence after rechallenge.
How this applies: No bedaquiline co-use; extract-related laboratory injury signal, not beverage equivalence or pair incidence.
No bedaquiline co-use; extract-related laboratory injury signal, not beverage equivalence or pair incidence.
Source 3: Original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 11, 2026
Population: 80 participants with nonalcoholic fatty liver disease.
ALT and AST decreased with the tested product.
How this applies: Different population/preparation and duration; enzyme improvement does not exclude idiosyncratic injury or establish bedaquiline co-use safety.
Different population/preparation and duration; enzyme improvement does not exclude idiosyncratic injury or establish bedaquiline co-use safety.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Editorial update | |
| Corrected missing spaces between numbers and units or words in the copy before registration; evidence and conclusions unchanged. | |
| Article prepared | |
| Prepared exact bedaquiline article with formulation-specific evidence and uncertainty. |
Article revision: 83fc00b507f80b84
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.