The short answer
Review Salvia miltiorrhiza root and rhizome with your prescribing team. Added bleeding and a protective spacing interval with dipyridamole are uncertain, especially when other antithrombotic medicines are also used.
What this answer covers
Oral Salvia miltiorrhiza root and rhizome preparations with oral dipyridamole. Injected isolated depside salts and unspecified multi-herb prescriptions are separate exposures.
- Supplement or preparation
- Radix et Rhizoma Salviae Miltiorrhizae
- Medication ingredient
- dipyridamole
Clinical studies involve different treatments
A short trial of injected Salvia depside salts with aspirin reported no bleeding tendency. A separate retrospective study of Salvia prescriptions with oral anticoagulants found an association with some bleeding outcomes, but important sensitivity results differed. Neither establishes the risk of this oral dipyridamole combination.
The preparation is important
An injected purified salt is not equivalent to an oral root or rhizome product. Some observational prescriptions also contained other herbs. Bring the plant part, dose, extraction method and complete formula to the pharmacist so evidence from a different preparation is not assumed to apply.
Review the whole antithrombotic regimen
The oral dipyridamole label describes use with warfarin after prosthetic valve replacement. In its cited studies, bleeding was no more frequent or severe than with warfarin alone, although rare increased surgical bleeding was reported. This does not establish safety with a new supplement or apply automatically to an aspirin-containing combination.
Know when to get help
Seek urgent care for bleeding that will not stop, vomiting blood or black, tarry stools. Tell your prescriber about the full supplement and medicine list. Do not stop prescribed antiplatelet treatment on your own to accommodate a supplement; ask the treating team to make a plan.
Evidence and practical considerations
Side effects & toxicity
Added bleeding or a required separation interval for Salvia miltiorrhiza root and rhizome with dipyridamole is not established.
- Exact scope
- Oral Salvia miltiorrhiza root and rhizome preparations with oral dipyridamole. Injected isolated depside salts and unspecified multi-herb prescriptions are separate exposures. with Exact dipyridamole RxCUI3521 IN. Oral single-ingredient tablets are distinguished from IV diagnostic use and fixed aspirin/dipyridamole combinations. IV evidence applies only where explicitly stated.
- Medication form and route
- Oral
What remains uncertain
- Other antithrombotic drugs, IV isolates and mixed prescriptions cannot establish the exact oral pair. Observational associations and negative short trials both have limitations.
Factors that may matter: Exact preparation and dose; Fasting versus fed dosing; Bleeding and ulcer history; Other medicines.
Read the supporting source summaries
Source 1: Current prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Prescription oral oral dipyridamole tablets users; short human pharmacology studies where described.
In cited warfarin trials, bleeding was no more frequent or severe than with warfarin alone; rare increased surgical bleeding reported. No pharmacokinetic interaction studies conducted with tablets.
How this applies: Exact current product label. Exact dipyridamole RxCUI3521 IN. Oral single-ingredient tablets are distinguished from IV diagnostic use and fixed aspirin/dipyridamole combinations. IV evidence applies only where explicitly stated.
Oral single-ingredient label, not IV diagnostic use or automatic aspirin-combination equivalence. No botanical bleeding trial.
Source 2: Original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 135 adults with stable angina completed ten-day outcome assessment.
Some thromboelastographic response improved; no reported bleeding tendency or adverse drug reactions.
How this applies: Indirect for oral dipyridamole tablets co-use; exact preparation and endpoint retained.
Abstract-only; isolated IV salts and aspirin are not oral root/rhizome with dipyridamole. Short trial cannot exclude uncommon harm.
Source 3: Original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Selected anticoagulant users with a documented bleeding event in a retrospective self-controlled case series.
Association with any bleeding in main analysis, but no major bleeding during exposure and first-event sensitivity analysis did not reproduce the overall any-bleeding association.
How this applies: Indirect for oral dipyridamole tablets co-use; exact preparation and endpoint retained.
Confounding, dispensing rather than ingestion, multi-herb exposure and selected case design; no isolated dipyridamole analysis or formulation-specific causal conclusion.
Source 4: Medication terminology
rxnav.nlm.nih.gov · Source check Sep 10, 2026
Population: Terminology.
dipyridamole is IN.
How this applies: Exact identity.
Not clinical evidence.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and article drafted. | |
| Research summary published |
Article revision: 3bf057e75227277a
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.