The short answer
Review hops before using it with lorazepam. Traditional sleep-aid use does not establish the amount of added sedation from this exact combination.
What this answer covers
Oral Humulus lupulus female-inflorescence preparations; not all plant parts or blends.
- Supplement or preparation
- Humulus lupulus
- Medication ingredient
- lorazepam
What the monograph says
The hops monograph describes traditional use for mild stress and sleep and possible driving impairment. It also lists no reported interactions.
What human metabolism testing showed
A standardized hops extract caused no clinically relevant interaction with the tested CYP probe drugs. This does not establish safety with lorazepam, which is mainly conjugated, or measure combined sleepiness.
Identify the actual sleep product
Check for female inflorescences, extract strength and added sedating ingredients. There is no tested spacing rule for hops with lorazepam.
Watch for impaired alertness
Lorazepam can affect alertness and coordination. Avoid driving if affected. Seek urgent help for severe difficulty waking or breathing, and tell the prescriber about alcohol, opioids and all other sedating products.
Evidence and practical considerations
Side effects & toxicity
Preparation-specific alertness caution is reasonable, but exact-pair additive sedation remains insufficiently established.
- Exact scope
- Oral Humulus lupulus female-inflorescence preparations; not all plant parts or blends. with Exact oral lorazepam tablets. Rapid conjugation to lorazepam glucuronide, which has no demonstrable CNS activity in animals. Oral tablet scope; injected lorazepam is not assigned the same supplement evidence.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact co-use trial. A standardized hops CYP probe study measured other-drug metabolism, not lorazepam sedation.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral lorazepam.
Can impair alertness and coordination; other CNS depressants can increase impairment. Opioid combinations have a specific respiratory-depression warning. Dependence and withdrawal require supervised changes. Rapid conjugation to lorazepam glucuronide, which has no demonstrable CNS activity in animals. Oral tablet scope; injected lorazepam is not assigned the same supplement evidence.
How this applies: Exact IN and labeled oral formulation; route, salt and metabolite distinctions retained.
No quantified risk for every herb or universal protective spacing interval. Opioid-specific evidence does not prove equal botanical respiratory risk.
Source 2: official herbal monograph
ema.europa.eu · Source check Sep 10, 2026
Population: Users of specified oral herbal preparations.
Traditional use for mild stress and aiding sleep; may impair driving. No interactions reported.
How this applies: Supports preparation-specific caution; does not establish additive sedation with the requested drug.
Traditional use is not proof of exact drug interaction. Part/extract boundaries and absence of clinical co-use data remain.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Sixteen peri/postmenopausal women.
No clinically relevant CYP probe interaction; alprazolam AUC declined slightly rather than showing inhibition.
How this applies: Original named medication and preparation only; indirect evidence for lorazepam. Comparator arms are not coadministration.
Other medications and metabolic endpoints, not lorazepam or additive sedation; absence of PK interaction is not absence of impairment.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: 6cb0ab77237e7363
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.