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Melatonin may add to fentanyl-related sedation, but surgical trials have not shown a uniform effect. Their monitored anesthesia regimens do not establish the safety of taking melatonin with a fentanyl patch at home.
Read the interaction guide →Melatonin may add to fluphenazine-related sleepiness. The exact clinical risk is not quantified, and laboratory or animal studies do not establish a safe dose or timing plan.
Read the interaction guide →Melatonin may add to flurazepam-related drowsiness and next-day impairment. Flurazepam’s long-lived active metabolite means a short timing gap cannot be assumed protective.
Read the interaction guide →Melatonin may add to hydromorphone-related drowsiness or impairment. The concern is reasonable, but an exact added respiratory-depression risk has not been measured.
Read the interaction guide →Review melatonin before adding it to iloperidone, especially if you already feel sleepy, dizzy or unsteady. The exact combination’s risk has not been quantified.
Read the interaction guide →Ask your prescriber before adding melatonin to imipramine. Prolonged-release melatonin product information reports more tranquility and difficulty performing tasks with the combination.
Read the interaction guide →Melatonin may add to lemborexant-related drowsiness and next-day impairment. Review co-use before adding it, especially when the supplement is being used as another sleep aid.
Read the interaction guide →Melatonin may add to drowsiness or impairment from oral levetiracetam. Interaction references flag this possibility, but controlled studies have not established how often it occurs or how risk changes with dose.
Read the interaction guide →Melatonin can cause drowsiness, so review it with your treatment team before combining it with lofexidine. Added impairment is a reasonable precaution, but its size has not been measured for this pair.
Read the interaction guide →Use melatonin with lorazepam only within a plan reviewed by your prescriber. Hospitals have studied regimens containing both, but those results do not establish unsupervised home-use safety.
Read the interaction guide →A matching name can refer to different products or preparations. Check the scope of the page you open. An absent result does not establish safety.
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