The short answer
Discuss vitamin E supplements with the prescriber while taking sertraline, especially with other bleeding-related medicines or planned surgery. A reported case involved several products, so the exact pair’s risk is uncertain.
What this answer covers
Oral supplemental vitamin E; unspecified preparation in a multi-product surgical case, distinct from ordinary dietary vitamin E.
- Supplement or preparation
- Vitamin E
- Medication ingredient
- sertraline
A case included this medicine and supplement
A patient taking sertraline, quinine, vitamin E and several herbs had extensive bleeding after breast surgery. Multiple exposures prevent assigning the cause to vitamin E and sertraline alone.
Separate precautions support review
Sertraline warns about bleeding. NIH guidance describes how supplemental vitamin E can affect platelets and clotting, especially with other bleeding-related medicines.
Dose thresholds are uncertain
NIH states that the amount needed for a clinically important interaction is unknown. A suggested high-dose range is not proof that every lower amount is safe or that food vitamin E must be avoided.
Coordinate changes before procedures
Tell the treating team the vitamin E amount, other supplements and medicines. Report unusual bruising or bleeding promptly. Do not stop sertraline or copy a supplement stopping interval without a plan.
Evidence and practical considerations
Side effects & toxicity
Conditional bleeding review supported by exact coexposure case and separate medicine/supplement precautions.
- Exact scope
- Oral supplemental vitamin E; unspecified preparation in a multi-product surgical case, distinct from ordinary dietary vitamin E. with Exact oral sertraline hydrochloride tablets. RxNorm IN36437 / PIN155137 hydrochloride tablets. Oral concentrate and its specific diluent instructions are distinct.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- Single heavily confounded case, unknown dose/formulation from abstract, no exact-pair frequency or guaranteed safe threshold.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed oral sertraline.
Label names tryptophan and St John’s wort in serotonin warnings and describes bleeding precautions. Tablet scope; grapefruit juice data do not automatically establish flesh equivalence.
How this applies: RxNorm IN36437 / PIN155137 hydrochloride tablets. Oral concentrate and its specific diluent instructions are distinct.
No universal supplement interval, event rate or preparation equivalence established.
Source 2: official nutrient guidance
ods.od.nih.gov · Source check Sep 10, 2026
Population: People using vitamin E.
Large supplemental amounts may affect platelets/clotting and increase bleeding with anticoagulant or antiplatelet treatment.
How this applies: General nutrient bleeding context with actual dose and formulation required.
Clinically significant dose threshold unknown; proposed amounts above 400 IU/day are not a guaranteed safety boundary. No exact sertraline event rate.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: One patient undergoing breast surgery.
Extensive postoperative bleeding required surgical re-exploration; multiple products may have contributed.
How this applies: Only the named drug, preparation, route and measured endpoints apply.
Abstract-only original; dose and formulation details unavailable. Multiple herbs, quinine and surgery confound attribution to vitamin E plus sertraline.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: d9a682d171c567ad
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.