The short answer
Review Valeriana officinalis before adding it to iloperidone, especially if you already feel sleepy, dizzy or unsteady. The exact combination’s risk has not been quantified.
What this answer covers
Oral Valeriana officinalis supplement with oral tablets; botanical preparation and medicine route retained.
- Supplement or preparation
- Valeriana officinalis
- Medication ingredient
- iloperidone
Why alertness deserves review
Iloperidone has cognitive or motor impairment precautions. Valeriana officinalis guidance raises alertness concerns, so your symptoms and other medicines matter.
A metabolic study is not a sedation trial
A valerian study using alprazolam as an enzyme probe did not establish a large metabolic interaction. It cannot determine alertness effects with iloperidone or show that every valerian extract behaves alike.
Identify the complete product
Bring the amount, preparation and other ingredients to the pharmacist. These sources do not provide a universal safe dose or a protective gap between the supplement and medicine.
Watch for impaired alertness
Iloperidone can affect alertness and coordination. Avoid driving if affected and contact the prescriber if added sleepiness, confusion or unsteadiness appears after a new product. Severe confusion, fainting or inability to wake needs urgent assessment.
Evidence and practical considerations
Side effects & toxicity
Conditional alertness review based on exact medication effects and supplement precautions; not proven pair-specific CNS depression.
- Exact scope
- Oral Valeriana officinalis supplement with oral tablets; botanical preparation and medicine route retained. with Exact iloperidone oral tablets. Exact RxNorm IN73178; oral iloperidone tablets. CYP2D6/CYP3A4 and QT precautions, not automatic electrolyte supplementation.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact-pair co-use trial identified; standalone or other-medicine findings and product differences prevent a uniform risk estimate.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed iloperidone.
Orthostatic hypotension, sedation, QT prolongation and baseline/periodic potassium-magnesium monitoring in at-risk patients; CYP2D6/CYP3A4 inhibitor sensitivity.
How this applies: Exact RxNorm IN73178; oral iloperidone tablets. CYP2D6/CYP3A4 and QT precautions, not automatic electrolyte supplementation.
No supplement-specific event rate, universal timing rule or untested route/preparation equivalence.
Source 2: official guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: People considering the specified supplement.
Possible but unproven sleep-inducing effect; advises against use with alcohol or sedatives. Mental dullness can occur; long-term safety is uncertain.
How this applies: Preparation-specific evidence; exact iloperidone co-use is not inferred from another medicine or route.
No iloperidone interaction trial. Chronic use can be followed by withdrawal symptoms when stopped abruptly.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Twelve healthy volunteers.
Alprazolam peak concentration increased modestly, but AUC and elimination half-life did not change significantly.
How this applies: Preparation-specific evidence; exact iloperidone co-use is not inferred from another medicine or route.
PK study is not a clinical sedation safety trial. Exact extract/species cannot resolve an unidentified valerian-root inventory item.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. |
Article revision: 49de9f5fd8bc0ca6
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.