The short answer
Strobilanthes cusia has not been shown to reduce midazolam absorption or clinical effect in people. Laboratory findings for indigo-plant preparations do not establish this exact botanical interaction.
What this answer covers
Exact Strobilanthes cusia identity; not Strobilanthes crispus, every Ban-Lan-Gen source, indigo naturalis or isolated indirubin.
- Supplement or preparation
- Strobilanthes cusia
- Medication ingredient
- midazolam
The available experiment was not a human interaction trial
A study found increased CYP3A4 gene activity with Ban-Lan-Gen extract and indirubin in cells. It did not measure midazolam concentrations, sedation or effectiveness in patients.
The botanical name cannot be substituted
Ban-Lan-Gen can refer to roots from several indigo plants. An effect of an isolated constituent or an incompletely identified preparation cannot be assigned to every Strobilanthes cusia product.
An enzyme signal is not a clinical dose rule
Midazolam is sensitive to CYP3A changes, but the amount and duration of an in-person interaction must still be established. Its oral, injected and nasal formulations have different exposure pathways.
Disclose the preparation before treatment
Show the treating team the plant identity, part and product label. Do not increase midazolam or use an arbitrary spacing interval to compensate for this unproven interaction. Lack of direct evidence is not proof of safety.
Evidence and practical considerations
Absorption & effectiveness
Laboratory transcription signal lacks exact botanical preparation, human exposure and clinical endpoint evidence; no proven midazolam absorption/effectiveness decrease.
- Exact scope
- Exact Strobilanthes cusia identity; not Strobilanthes crispus, every Ban-Lan-Gen source, indigo naturalis or isolated indirubin. with Midazolam6960 IN; oral hydrochloride syrup, IV/IM hydrochloride and intranasal midazolam distinguished.
- Medication form and route
- oral medication; intravenous medication; intramuscular medication; intranasal medication; oral supplement
What remains uncertain
- No unmeasured pair incidence, blanket class transfer or arbitrary spacing interval.
Factors that may matter: Preparation; Dose; Other medicines; Organ function.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed midazolam
CYP3A metabolism, CNS-depressant and respiratory risks; not intended for chronic home sedation.
How this applies: Exact midazolam RxCUI 6960 IN, with stated salt/formulation/route bridge.
Adult oral probe trials not automatic pediatric dosing or nasal/injection interaction magnitude.
Source 2: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed midazolam
Sedation/respiratory and CYP3A interaction precautions.
How this applies: Exact midazolam RxCUI 6960 IN, with stated salt/formulation/route bridge.
Bypasses intestinal absorption; oral exposure findings cannot be assigned unchanged.
Source 3: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed midazolam
CNS-depressant and CYP3A interaction precautions; formulation-specific rescue instructions.
How this applies: Exact midazolam RxCUI 6960 IN, with stated salt/formulation/route bridge.
Not oral procedural dosing; do not delay prescribed seizure rescue to implement an invented herbal gap.
Source 4: original laboratory study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Cell-based experiments.
Increased CYP3A4 transcriptional activity in laboratory models.
How this applies: Ban-Lan-Gen can refer to several plant species; abstract does not establish authenticated Strobilanthes cusia preparation, human midazolam PK or clinical effectiveness.
Ban-Lan-Gen can refer to several plant species; abstract does not establish authenticated Strobilanthes cusia preparation, human midazolam PK or clinical effectiveness.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Prepared exact midazolam article with formulation-specific evidence and uncertainty. |
Article revision: 7be3a75918736cd5
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.