The short answer
A specific SAMe interaction with aripiprazole lauroxil is not established. Discuss the supplement with your mental-health prescriber before adding it.
What this answer covers
Oral S-adenosylmethionine supplement; concentrated mood product distinct from ordinary dietary nutrients.
- Supplement or preparation
- S-Adenosylmethionine
- Medication ingredient
- aripiprazole lauroxil
Mood history matters
NCCIH cautions that SAMe may worsen mania in people with bipolar disorder. This is a supplement concern, not proof that aripiprazole lauroxil causes a new interaction.
The human trial used other medicines
A small SAMe study added it to serotonin-reuptake inhibitors. Its results do not establish the safety or benefit of adding it to aripiprazole lauroxil.
Do not convert mechanism into a diagnosis
General advice about serotonin-increasing products does not establish serotonin syndrome with this exact combination. Review all antidepressants and supplements as well as the prescribed antipsychotic.
Keep treatment supervised
Bring the product and your reason for taking it to the prescriber. Do not use SAMe to replace or offset aripiprazole lauroxil, and report substantial changes in sleep, energy or behavior.
Evidence and practical considerations
Side effects & toxicity
Exact-pair side-effect claim remains insufficient; psychiatric history and other medicines justify individual review.
- Exact scope
- Oral S-adenosylmethionine supplement; concentrated mood product distinct from ordinary dietary nutrients. with Exact aripiprazole lauroxil long-acting intramuscular suspension. Exact RxNorm IN1673265, ester prodrug, not oral aripiprazole. ARISTADA maintenance injection and ARISTADA INITIO initiation product distinguished; oral aripiprazole clinical findings require explicit active-metabolite bridge.
- Medication form and route
- intramuscular
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact combination trial or measured event rate. General serotonin advice cannot be assigned automatically to an antipsychotic.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed aripiprazole lauroxil.
Prodrug hydrolyzed to active aripiprazole; long-acting injection, cognitive/motor and orthostatic precautions; duration-dependent CYP3A4 inducer instructions.
How this applies: Exact RxNorm IN1673265, ester prodrug, not oral aripiprazole. ARISTADA maintenance injection and ARISTADA INITIO initiation product distinguished; oral aripiprazole clinical findings require explicit active-metabolite bridge.
No supplement-specific event rate, universal timing rule or untested route/preparation equivalence.
Source 2: official supplement guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: People considering SAMe.
Possible interaction with serotonin-increasing medicines and supplements; bipolar disorder and limited long-term safety warrant review.
How this applies: Supplement-only concern, not a serotonin-syndrome warning in the antipsychotic label.
General supplement psychiatric precautions, not an exact aripiprazole lauroxil interaction or incidence.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 73 serotonin reuptake inhibitor nonresponders with major depression.
Response and remission favored SAMe; discontinuation due to adverse events was not significantly different.
How this applies: Other-medicine clinical context only.
Serotonin-reuptake-inhibitor augmentation trial; no aripiprazole lauroxil coexposure established.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. |
Article revision: 9bf2916df733544c
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.