The short answer
Magnesium-containing oral products can interfere with delafloxacin tablet absorption. For the products named in the label, take delafloxacin at least 2 hours before or 6 hours after the mineral product. A two-hour gap in either direction would miss part of the instruction.
What this answer covers
Oral delafloxacin meglumine tablets with magnesium-containing oral antacids and products. The interaction concerns absorption in the digestive tract, not every route or trace exposure.
- Supplement or preparation
- Magnesium
- Medication ingredient
- delafloxacin
Which products are covered?
The prescribing information names magnesium-containing antacids and the patient instructions include magnesium products. The source does not isolate magnesium glycinate, citrate or every other supplement salt in a clinical experiment. It is reasonable to review their timing, while retaining the actual salt and amount rather than assigning each the same unmeasured effect.
How do I arrange the two doses?
If delafloxacin is taken first, wait at least 2 hours before the magnesium product. If the mineral is first, wait at least 6 hours before delafloxacin. The order matters. Ask the pharmacist to fit repeated supplement or antacid doses around the prescribed antibiotic schedule instead of using an interval remembered from another antibiotic.
How much does the interaction change treatment?
The current label warns that overlapping oral products can leave less antibiotic available in the body, but it does not quantify a mineral-only effect in a human trial. A percentage measured with ciprofloxacin or moxifloxacin cannot be assigned to delafloxacin. The precaution supports following the label schedule, without predicting that an individual infection will fail treatment.
Does this change my need for the mineral?
A scheduling precaution does not establish that the antibiotic depletes a nutrient or makes a prescribed supplement unnecessary. Keep the reason for treatment, exact product and dose available when discussing a plan. Tablets and intravenous delafloxacin have different administration considerations; an oral spacing instruction should not be used to manage an infusion.
Evidence and practical considerations
Absorption & effectiveness
Magnesium-containing oral products can interfere with delafloxacin tablet absorption. For the products named in the label, take delafloxacin at least 2 hours before or 6 hours after the mineral product. A two-hour gap in either direction would miss part of the instruction.
- Exact scope
- magnesium-containing oral antacids and products with oral delafloxacin meglumine tablets, 450 mg active delafloxacin equivalent
- Medication form and route
- oral
- Timing or duration
- Precaution at each overlapping oral dose throughout the antibiotic course; mineral-specific clinical duration and effect magnitude are not established.
What remains uncertain
- Exact-drug regulatory guidance, without an independently inspected human mineral-only delafloxacin trial. No magnitude of treatment failure, nutrient depletion or all-salt equivalence is established.
Factors that may matter: exact salt and dose; order and interval between oral doses; combination-product ingredients; oral versus nonoral route.
Read the supporting source summaries
Source 1: regulatory product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Adults prescribed oral BAXDELA tablets; injection instructions kept separate.
Take tablets at least 2 hours before or 6 hours after magnesium/aluminum antacids, iron and zinc/iron multivitamins. Patient instructions also name Mg, Al, Fe and Zn products. Tablets can be taken with or without food. Calcium/magnesium solutions are prohibited in the same IV line; that is not an oral calcium trial.
How this applies: Explicit active-moiety equivalence supports oral meglumine tablets under parent RxCUI 1927663. Oral and IV instructions are not interchangeable. Article-specific counterparty: magnesium-containing oral antacids and products.
No individual mineral effect size or direct oral copper/calcium trial is supplied. Label guidance is not an independent human interaction experiment.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Exact-drug product guidance and original research checked; complete private article prepared with evidence limitations and current-claim adjudication. | |
| Research summary published |
Article revision: 209b32c95464cb46
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.