The short answer
Avoid grapefruit products while taking pazopanib, and have a grapefruit fruit extract checked before use. The product information warns about increased drug exposure, but it does not prove that every extract causes liver injury.
What this answer covers
Citrus paradisi fruit extract in relation to oral pazopanib. Grapefruit juice/fruit and unspecified concentrated extracts are not identical exposures.
- Supplement or preparation
- Citrus Paradisi (Grapefruit) Fruit Extract
- Medication ingredient
- pazopanib
Check the exact treatment
This review concerns oral pazopanib tablets containing the hydrochloride salt, with doses expressed as pazopanib. It is used for specified advanced kidney cancer or soft-tissue sarcoma settings. Keep the prescribed fasting schedule and do not crush the tablets.
The warning concerns drug exposure
Pazopanib’s instructions say not to eat grapefruit or drink its juice, and warn that grapefruit products may increase the amount of medicine in the body. This is an exposure concern associated with metabolism, not a measured liver-injury rate for an unspecified extract.
Extracts are not interchangeable with juice
A fruit extract may concentrate some constituents and remove others. Its weight does not establish the amount of enzyme-inhibiting compounds. Do not assume that a seed extract, juice, flesh extract or flavored product has an identical effect just because the plant name is similar.
Keep the prescribed food instructions
Pazopanib is taken on an empty stomach, at least one hour before or two hours after food, and tablets should not be crushed. Keep that schedule and the liver-monitoring plan. A time gap from grapefruit is not a validated substitute for the avoidance instruction.
Evidence and practical considerations
Side effects & toxicity
The grapefruit exposure precaution is supported; a universal fruit-extract liver-injury claim is not established.
- Exact scope
- Citrus paradisi fruit extract in relation to oral pazopanib. Grapefruit juice/fruit and unspecified concentrated extracts are not identical exposures. with RxNorm 714438 IN pazopanib. Current exact oral product: Pazopanib oral hydrochloride tablets. Salt/formulation named explicitly; no transfer to unrelated drugs or routes.
- Medication form and route
- Oral
What remains uncertain
- No exact standardized fruit-extract co-use trial or liver-injury effect size. Explicit grapefruit-product precaution is separate from the original organ-toxicity assertion.
Factors that may matter: Exact oral formulation and supplement preparation; Drug exposure versus clinical outcomes; Dose, duration and other medicines; Individual monitoring plan.
Read the supporting source summaries
Source 1: Current original prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed the exact oral formulation.
Severe hepatotoxicity and bleeding warnings; CYP3A interaction precautions; avoid grapefruit products.
How this applies: RxNorm 714438 IN pazopanib. Current exact oral product: Pazopanib oral hydrochloride tablets. Salt/formulation named explicitly; no transfer to unrelated drugs or routes.
Exact current oral product source, not a clinical trial of every supplement. Formulation, dose, population and mechanism remain explicit.
Source 2: Medication terminology
rxnav.nlm.nih.gov · Source check Sep 10, 2026
Population: Terminology.
pazopanib is IN.
How this applies: Exact ingredient.
Not clinical evidence.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Sources checked and article drafted. |
Article revision: bbb848f5d3f01a0b
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.