What is it used for?
Source of (the) essential amino acid(s) (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, valine) for the maintenance of good health/involved in (muscle) protein synthesis [Source note 4].
Source of (the) non-essential amino acid(s) (alanine, arginine, aspartic acid, glutamic acid, glycine, proline, serine, tyrosine) involved in (muscle) protein synthesis [Source note 5].
Source of (the essential amino acid) lysine to help in collagen formation/synthesis [Source note 6].
Helps reduce joint pain associated with osteoarthritis [Source note 7].
Helps reduce osteoarthritis-related joint pain [Source note 8].
Helps manage/in the management of joint pain [Source note 9].
Notes:
The above uses can be combined on the product label (e.g. Source of essential amino acids for the maintenance of good health and non-essential amino acids involved in muscle protein synthesis).
The terms 'Helps' or 'Helps to' can be used interchangeably on the label.
What this guide covers
For the purpose of this reference, hydrolyzed collagen has no jelling power and is soluble in cold water [Source note 1].The average molecular weight of hydrolyzed collagen is approximately 4 kDa (i.e. 2-6 kDa) [Source note 2].
Who does this guide cover?
Adults 18 years and older
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
Quantities
Source of (the) essential amino acid(s)(histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, valine)
2.6-10 grams hydrolyzed collagen, per day [Source note 10].
OR
| Essential amino acids | Minimum dose (mg/day) 5% of the RDA¹ | Maximum dose of hydrolyzed collagen (g/day)² |
|---|---|---|
| L-Histidine | 49 mg | 10 g |
| L-Isoleucine | 66.5 mg | 10 g |
| L-Leucine | 147 mg | 10 g |
| L-Lysine | 133 mg | 10 g |
| L-Methionine | 66.5 mg | 10 g |
| L-Phenylalanine | 115.5 mg | 10 g |
| L-Threonine | 70 mg | 10 g |
| L-Valine | 84 mg | 10 g |
¹Minimum doses have been calculated as 5% of each specific amino acid Recommended Dietary Allowance with a reference weight of 70 kg [Source note 11]. ²Maximum dose [Source note 12].
Source of (the) non-essential amino acid(s) (alanine, arginine, aspartic acid, glutamic acid, glycine, proline, serine, tyrosine)
2.6-10 grams hydrolyzed collagen, per day [Source note 13].
OR
| Non-Essential amino acids | Minimum dose (mg/day) 5% of the RDA¹ | Maximum dose of hydrolyzed collagen (g/day)² |
|---|---|---|
| L-Alanine | 181.5 mg | 10 g |
| L-Arginine | 208.5 mg | 10 g |
| L-Aspartic acid | 325 mg | 10 g |
| L-Glutamic acid | 750 mg | 10 g |
| Glycine | 160 mg | 10 g |
| L-Proline | 259.5 mg | 10 g |
| L-Serine | 175.5 mg | 10 g |
| L-Tyrosine | 139 mg | 10 g |
¹Minimum doses have been calculated as 5% of each specific amino acid Mean Intake [Source note 14] ²Maximum dose [Source note 15].
Source of lysine
| Essential amino acids | Minimum dose(mg/day) 5% of the RDA¹ | Maximum dose of hydrolyzed collagen (g/day)² |
|---|---|---|
| L-Lysine | 133 mg | 10 g |
¹Minimum doses have been calculated as 5% of Recommended Dietary Allowance with a reference weight of 70 kg [Source note 16]. ²Maximum dose [Source note 17].
Joint pain
1.2-10 grams hydrolyzed collagen, per day [Source note 18].
How is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
How long is it used?
Joint pain
Use for at least 5 months to see beneficial effects [Source note 19].
Warnings and precautions
Joint pain
Ask a healthcare professional if symptoms worsen.
Products providing more than 2.8 g hydrolyzed collagen, per day
Ask a healthcare professional before use if you are pregnant or breastfeeding [Source note 20].
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
When using this product you may experience gastrointestinal discomfort/disturbances [Source note 21].
Storage
Must be established in accordance with the requirements described in the applicable product regulations.
All products (information for industry; optional for labelling depending on the packaging)
To be protected from heat and moisture [Source note 22].
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source material(s) | Source information / Part(s) |
|---|---|---|---|
| Hydrolyzed collagen |
| Bovine | Bovine skin/hide split |
| Hydrolyzed collagen |
| Porcine |
|
| Hydrolyzed collagen |
| Fish |
|
| Hydrolyzed collagen |
| Chicken | Cartilage |
References: Proper name: NIH 2023, ICIDH 2008; Common names: NIH 2023, ICIDH 2008, Moskowitz 2000; Source information: Schauss et al 2012, FCC 7 2010, Schrieber and Gareis 2007, Baziwane and He 2003.
Other ingredients
Must be chosen from the current source ingredient database and must meet the limitations outlined in the database.
Preparation and quality requirements
The finished product specifications must be established in accordance with the requirements described in the Natural and Non-Prescription Health Products (source authority) source’s product quality guidance.
The active ingredient must comply with the requirements outlined in the source ingredient database .
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- March 28, 2024
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
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