What is it used for?
Source of antioxidants/Provides antioxidants [Source note 2].
Source of antioxidants/Provides antioxidants that help fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals [Source note 3].
(Traditionally) used in Herbal Medicine to help prevent (recurrent) urinary tract infections (UTIs) (in women) [Source note 4].
Helps prevent (recurrent) urinary tract infections (UTIs) (in women) [Source note 5].
The above uses can be combined on the product label if from the same traditional or non-traditional system of medicine (e.g., Source of antioxidants and helps prevent recurrent urinary tract infections in women).
For multi-ingredient products:
To prevent the product from being represented as a "traditional medicine", any indicated traditional use claim must refer to the specific active ingredient(s) and recognized traditional system of medicine from which the claim originates when 1) both traditional and modern claims are present or 2) when claims originate from multiple systems of traditional medicine (e.g., Dried cranberry juice is traditionally used in Herbal Medicine to help prevent urinary tract infections).
When ALL of the active ingredients (MIs) in the product are used within the SAME identified system of traditional medicine AND the product makes ONLY traditional claims, listing of MIs in the traditional claim(s) is not required.
Who does this guide cover?
Adults 18 years and older
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
Quantities
Antioxidant
Method of preparation: Juice powdered
Not to exceed 1,200 milligrams of dried fruit juice, per day [Source note 6].
(Recurrent) urinary tract infection
Method of preparation: Juice powdered
400 – 1,200 milligrams of dried fruit juice, per day [Source note 7].
Note: Applicants are not to provide a quantity of crude equivalent (QCE) and/or extract ratio.
How is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
How long is it used?
Antioxidant
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
(Recurrent) urinary tract infection
Use for at least 4 weeks to see beneficial effects [Source note 8].
Warnings and precautions
All products
Ask a healthcare professional before use if you have a history of kidney stones [Source note 9].
Ask a healthcare professional before use if you are taking blood thinners [Source note 10].
(Recurrent) urinary tract infection
Ask a healthcare professional if symptoms persist or worsen.
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Storage
Must be established in accordance with the requirements described in the applicable product regulations.
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source material(s) | Source information / Part(s) | Source information / Preparation(s) |
|---|---|---|---|---|
| Vaccinium macrocarpon |
| Vaccinium macrocarpon | Fruit | Dry |
References: Proper name: USDA 2024; Gardner and McGuffin 2013; Common names: Jepson and Craig 2008; Mills and Bone 2005; Stothers 2002; Upton 2002; Siciliano 1996; Source information: Jepson and Craig 2008; Mills and Bone 2005; Stothers 2002; Upton 2002; Siciliano 1996.
Other ingredients
Must be chosen from the current source ingredient database and must meet the limitations outlined in the database.
Preparation and quality requirements
The finished product specification must be established in accordance with the requirements described in the source authority Quality of supplements.
The active ingredient must comply with the requirements outlined in the source ingredient database.
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- March 27, 2026
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
Taking a medication too?
Explore our supplement–medication interaction checker. Its coverage and review status are shown with the results; a missing finding does not establish that a combination is safe.