What is it used for?
(Used in Herbal Medicine (as a demulcent) to) help(s) relieve minor inflammations of the gastrointestinal tract [Source note 2].
(Used in Herbal Medicine (as a demulcent) to) help(s) relieve abdominal pain and burning sensation in the stomach [Source note 3].
Note: The above uses can be combined on the product label (e.g., Used in Herbal Medicine to help relieve minor inflammations of the gastrointestinal tract and abdominal pain and burning sensation in the stomach).
What this guide covers
The solidus (/) indicates that the terms and/or statements are synonymous. Either term or statement may be selected by the applicant on the label.
Who does this guide cover?
As listed below.
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
In order to ensure efficacy, DGL must be mixed with saliva. Thus, the acceptable dosage forms are: Bar, chewable; Chewable gel¹; Granule²; Tablet, chewable.
¹Gummy
²To be chewed
Quantities
Method of preparation: Prepared and dry
| Subpopulation(s) ¹,² | Subpopulation(s) ¹,² | Deglycyrrhizinated licorice extract (mg) / Minimum/single dose | Deglycyrrhizinated licorice extract (mg) / Maximum/single dose | Deglycyrrhizinated licorice extract (mg) / Frequency/day |
|---|---|---|---|---|
| Children | 3-4 years | 63 mg | 253 mg | 3 times |
| Children | 5-9 years | 95 mg | 380 mg | 3 times |
| Children | 10-11 years | 190 mg | 760 mg | 3 times |
| Adolescents | 12-14 years | 190 mg | 760 mg | 3 times |
| Adolescents | 15-17 years | 380 mg | 1520 mg | 3 times |
| Adults | 18 years and older | 380 mg | 1520 mg | 3 times |
¹Children and adolescent doses were calculated as a fraction of the adult dose [Source note 4]. The use of licorice in children and adolescents is supported by the following references: McIntyre 2005; Schilcher 1997; Bove 1996.
²Adult doses are supported by Pizzorno and Murray 2006.
How is it used?
Chew between meals or 20 minutes before meals [Source note 5].
How long is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Warnings and precautions
Ask a healthcare professional if symptoms persist or worsen.
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Storage
Must be established in accordance with the requirements described in the applicable product regulations.
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source material(s) | Source information / Part(s) |
|---|---|---|---|
| Deglycyrrhizinated licorice |
|
|
|
References: Proper name: source ingredient database 2025; Common names: Pizzorno and Murray 2006; Blumenthal et al. 2000; Source information: USDA 2024; USP-NF 2024; PPRC 2020; BP 2008; Ph. Eur. 2008.
Other ingredients
Must be chosen from the current source ingredient database and must meet the limitations outlined in the database.
Preparation and quality requirements
The finished product specifications must be established in accordance with the requirements described in the source authority source’s product quality guidance.
The active ingredient must comply with the requirements outlined in the source ingredient database.
The finished product must not contain more than 3% of the original quantity of glycyrrhizic acid found in the source material [Source note 6].
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- January 31, 2025
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
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