What is it used for?
Source of (an) antioxidant(s)/Provides (an) antioxidant(s) [Source note 2].
Source of (an) antioxidant(s)/Provides (an) antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals [Source note 3].
Helps relieve joint pain and inflammation [Source note 4].
Note: For source of antioxidant(s) claims, the singular should be used on the label when the product only contains one active ingredient (MI) (single compound) associated with the claim (e.g. curcumin); the plural form should be used when the product formulation contains more than one MI with such properties or one MI containing several compounds with antioxidant properties such as curcuminoids.
What this guide covers
As enhanced absorption formulations are often used for Turmeric and its constituents, this is a reminder that enhanced absorption dosage forms/formulations are not covered by Natural and Non-prescription Health Products Directorate's references and should be submitted as Class III submissions with supporting evidence.
Who does this guide cover?
Adults 18 years and older
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
Quantities
Concentrated Turmeric Extracts
Methods of preparation: Standardized Extracts
Antioxidant
Extract standardized to 75% Curcuminoids or more; Not to exceed 1500 milligrams curcuminoids per day and 500 milligrams per single dose [Source note 5].
Note: Optional: The potency constituent, curcumin, can be included.
Relief of joint pain/inflammation
Extract standardized to 75% Curcuminoids or more; Providing 1500 milligrams curcuminoids, per day; Not to exceed 500 milligrams per single dose [Source note 6].
Note: Optional: The potency constituent, curcumin, can be included.
Curcuminoids
Antioxidant
Not to exceed 1500 milligrams curcuminoids per day and 500 milligrams per single dose [Source note 7].
Note: Optional: The potency constituent, curcumin, can be included.
Relief of joint pain/inflammation
1500 milligrams curcuminoids, per day; Not to exceed 500 milligrams per single dose [Source note 8].
Note: Optional: The potency constituent, curcumin, can be included.
Curcumin
Antioxidant
Not to exceed 1200 milligrams curcumin per day and 400 milligrams per single dose [Source note 9].
Relief of joint pain/inflammation
1200 milligrams curcumin, per day; Not to exceed 400 milligrams per single dose [Source note 10].
How is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
How long is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Warnings and precautions
All products
Ask a healthcare professional before use if you are pregnant or breastfeeding.
Ask a healthcare professional before use if you have a liver or biliary disorder [Source note 11].
Ask a healthcare professional before use if you are taking medications including blood thinners [Source note 12].
Stop use and ask a healthcare professional if you experience any new symptoms including yellowing of the eyes or skin, dark urine, nausea, vomiting, stomach pain [Source note 13].
Relief of joint pain/inflammation
Ask a healthcare professional if symptoms persist or worsen.
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Storage
Must be established in accordance with the requirements described in the applicable product regulations.
Conditions for combined preparations
The finished product should not exceed a total amount of curcuminoids of 500 mg per dose and 1500 mg per day.
The finished product should not exceed a total amount of curcumin of 400 mg per dose and 1200 mg per day.
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source material(s) | Source information / Part(s) | Source information / Preparation(s) |
|---|---|---|---|---|
| Curcuma longa |
| Curcuma longa | Rhizome | Dry |
| Curcuminoids | Curcuminoids | Curcuma longa | Rhizome | Isolate |
| (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione | Curcumin | Curcuma longa | Rhizome | Isolate |
| (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione | Curcumin | N/A | N/A | Synthetic |
References: Proper names: Curcuminoids: USP-NF 2023; EFSA 2017; Curcumin: RSC 2023; Turmeric: USDA 2023; Common names: Curcuminoids: USP-NF 2023; EFSA 2017; Curcumin: Goel et al. 2008; Boon and Smith 2004; Deodhar et al. 1980; Turmeric: USDA 2023; PPRC 2020; McGuffin et al. 2000; Source information: PPRC 2020; Goel et al. 2008; Boon and Smith 2004; ESCOP 2003; Blumenthal et al. 2000; Deodhar et al. 1980.
Other ingredients
Ingredients must be chosen from the current source ingredient database and must meet the limitations outlined in that database, the Food and Drug Regulations (FDR), and the current Cosmetic Ingredient Hotlist, when relevant.
Preparation and quality requirements
The finished product specifications must be established in accordance with the requirements described in the Natural and Non-prescription Health Products (source authority) source’s product quality guidance.
The active ingredient must comply with the requirements outlined in the source ingredient database.
The active ingredients may comply with pharmacopoeial references. For example, as per USP-NF 2023, curcuminoids is defined as a partially purified natural complex of diaryl heptanoid derivatives isolated from Turmeric, Curcuma longa L. The ingredient contains NLT 95.0% of curcuminoids, calculated on the dried basis, as the sum of curcumin, desmethoxycurcumin, and bisdesmethoxycurcumin. It contains not less than 70% and no more than 80% curcumin, NLT 15.0% and NMT 25.0% of desmethoxycurcumin, and NLT 2.5% and NMT 6.5% of bisdesmethoxycurcumin.
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- September 26, 2025
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
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