What is it used for?
Helps to maintain and/or support cardiovascular health [Source note 2].
Helps to reduce the frequency of migraine headaches and associated nausea and vomiting when taken as a prophylactic/preventative [Source note 3].
Source of (an) antioxidant(s)/Provides (an) antioxidant(s) [Source note 4].
Source of (an) antioxidant(s)/Provides (an) antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals [Source note 5].
Notes:
The above uses can be combined on the product label (e.g., Helps to maintain and support cardiovascular health and to reduce the frequency of migraine headaches and associated nausea and vomiting when taken as a preventative).
The terms 'Helps' or 'Helps to' can be used interchangeably on the label.
If Coenzyme Q10 is combined with other active ingredients with antioxidant properties, there is an option to use the antioxidant claims in plural. The singular should be used when the product only contains one chemical substance (e.g., Coenzyme Q10) as the active ingredient associated with the antioxidant claim.
What this guide covers
The solidus (/) indicates that the terms and/or statements are synonymous. Either term or statement may be selected by the applicant on the label.
Who does this guide cover?
Adults 18 years and older
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
Quantities
Antioxidant
Not to exceed 300 milligrams of Coenzyme Q10, per day [Source note 6]
Cardiovascular health
30 - 300 milligrams of Coenzyme Q10, per day [Source note 7]
Migraine prophylaxis
150 - 300 milligrams of Coenzyme Q10, per day [Source note 8]
How is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
How long is it used?
Migraine prophylaxis/prevention
Use for at least 3 months to see beneficial effects [Source note 9].
Other uses
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Warnings and precautions
All products
Ask a healthcare professional before use if you are pregnant or breastfeeding.
Ask a healthcare professional before use if you are taking blood pressure medication [Source note 10].
Products providing more than 100 mg of Coenzyme Q10 per day
Ask a healthcare professional before use if you are taking blood thinners [Source note 11].
Migraine prophylaxis/prevention
Ask a healthcare professional if migraine frequency increases and associated nausea and vomiting persist or worsen.
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Storage
Must be established in accordance with the requirements described in the applicable product regulations .
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source ingredient(s) | Source information / Source material(s) | Source information / Part(s) | Source information / Preparation(s) |
|---|---|---|---|---|---|
| 2,5-Cyclohexadiene-1,4-dione, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl |
| N/A |
| Whole | Biosynthesis |
| 2,5-Cyclohexadiene-1,4-dione, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl |
| Coenzyme Q10 | N/A | N/A | Synthetic |
References: Proper name: USP-NF 2024; Common names: Brayfied and Cadart 2024; RSC 2024; USP-NF 2024; Storch et al. 2007; Park et al. 2005; Source information: Lipshutz et al. 2005; Kawamukai 2002; Lipshutz et al. 2002; Szkopinska 2000; Yoshida et al. 1998; Zhao et al.1997.
Other ingredients
Must be chosen from the current source ingredient database and must meet the limitations outlined in the database.
Preparation and quality requirements
The finished product specifications must be established in accordance with the requirements described in the source authority source’s product quality guidance.
The active ingredient must comply with the requirements outlined in the source ingredient database.
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- January 31, 2025
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
Taking a medication too?
Explore our supplement–medication interaction checker. Its coverage and review status are shown with the results; a missing finding does not establish that a combination is safe.