What is it used for?
Products containing Betaine as a active ingredient (source ingredient: betaine or betaine hydrochloride)
Helps to support liver function [Source note 2].
Products containing Betaine hydrochloride as a active ingredient or as a source ingredient
Helps to support digestion [Source note 3].
Digestive aid [Source note 4].
Who does this guide cover?
Adults 18 years and older
How is it taken?
Oral
Which forms are covered?
this reference excludes foods or food-like dosage forms as indicated in the Compendium of references Guidance Document.
Quantities
Liver function
Betaine (source ingredient: betaine or betaine hydrochloride)
500 - 4,000 milligrams of Betaine, per day [Source note 5].
Helps to support digestion/Digestive aid
Betaine (source ingredient: betaine hydrochloride) or betaine hydrochloride
| Medicinal iIngredient(s) | Source ingredient(s) | Minimum/day | Maximum/day | Maximum/day |
|---|---|---|---|---|
| Betaine | Betaine hydrochloride | 137 mg | 2,670 mg | |
| Betaine hydrochloride | N/A | 180 mg | 3,500 mg |
How is it used?
Products containing Betaine hydrochloride (as a active ingredient or as a source ingredient)
Take with a meal/food [Source note 7].
How long is it used?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Warnings and precautions
All products
Ask a healthcare professional before use if you are pregnant or breastfeeding.
Products containing Betaine hydrochloride (as a active ingredient or as a source ingredient)
Ask a healthcare professional before use if you have a peptic ulcer or excess stomach acid [Source note 8].
Products providing 600 milligrams or more of Betaine or 780 milligrams or more of Betaine hydrochloride as a active ingredient, per day
Ask a healthcare professional before use if you have high cholesterol [Source note 9].
When should it be avoided?
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Possible side effects
The reference does not require an additional label statement in this section. This does not establish an absence of risk.
Storage
Must be established in accordance with the requirements described in the applicable product regulations.
Conditions for combined preparations
No permitted combinations between the two active ingredients or their source ingredients listed in Table 1.
Preparation details
Ingredient identity, preparation requirements, and other details that define the scope of this guide.
Ingredients and preparations
| Proper name(s) | Common name(s) | Source information / Source ingredient(s) | Source information / Source material(s) | Source information / Part(s) | Source information / Preparation(s) |
|---|---|---|---|---|---|
|
|
| Beta vulgaris | Root | Isolate |
|
|
| N/A | N/A | Synthetic |
| 1-Carboxy-N,N,N- trimethylmethanaminium chloride | Betaine hydrochloride | N/A | Beta vulgaris | Root | Isolate |
References: Proper names: Brayfield and Cadart 2024; Moffat et al. 2024; RSC 2024; Common names: source ingredient database 2025; Source information: FCC 2025; Brayfield and Cadart 2024; Moffat et al. 2024; RSC 2024; DNP 2023; Allen Jr. 2012.
Other ingredients
Must be chosen from the current source ingredient database and must meet the limitations outlined in the database.
Preparation and quality requirements
The finished product specifications must be established in accordance with the requirements described in the source authority source’s product quality guidance.
The active ingredient must comply with the requirements outlined in the source ingredient database.
Guide change history
Updates to this SupplementSafety.org guide.
Minor updates
Updated guide wording, organization, and source presentation. Added our editorial change history.
Initial release
Initial SupplementSafety.org guide prepared from source reference material.
Validation: Not yet completed. Editorial updates do not constitute clinical validation.
Sources
Source information
This guide organizes source material about uses, preparations, amounts, and precautions. Read the conditions alongside each statement; the information may apply only to particular preparations or populations.
The source document includes supporting references. We have not independently summarized or assessed every cited study for this guide.
- Source document version
- January 30, 2026
- Source captured
- Aug 15, 2026
- Editorial work
- Editorial preparation. Independent clinical review has not been recorded for this guide.
Full citations are available through the link above. Verification is required to open them; reading this guide does not require verification.
Taking a medication too?
Explore our supplement–medication interaction checker. Its coverage and review status are shown with the results; a missing finding does not establish that a combination is safe.