The short answer
The added bleeding risk from feverfew with meclofenamate is uncertain. Review the exact product, dose and your bleeding history with your prescriber.
What this answer covers
Oral feverfew with oral meclofenamate sodium capsules. Exact formulation, dose and duration matter; other NSAIDs and other supplement preparations are not interchangeable.
- Supplement or preparation
- Tanacetum parthenium
- Medication ingredient
- meclofenamate
What the evidence shows
A case report described vaginal bleeding and altered coagulation tests in a woman taking feverfew 800 mg three times daily for nine months. It raises a safety signal, but she was not reported as taking this NSAID in the inspected abstract. A single case cannot establish combination incidence or stomach injury.
Consider this medicine’s own effects
The current sodium-capsule label reports little or no platelet or bleeding-time effect in a one-week healthy-volunteer study, unlike aspirin. It also reports dose-related fecal blood loss and retains serious GI warnings. Those findings should be considered together: a small platelet effect does not guarantee stomach safety or prove that a supplement interaction cannot occur.
Review the exact product
Check the Tanacetum parthenium preparation, daily dose and duration. The reported exposure was prolonged and substantial, so it should not be treated as a measured risk for every dose. Discuss use before procedures and disclose other medicines that affect bleeding.
Know when to get help
oral meclofenamate sodium capsules can cause serious GI bleeding even without a supplement. Seek urgent care for vomiting blood or black, tarry stools, and report persistent stomach pain or unusual bleeding. Tell your prescriber about other pain medicines, aspirin and anticoagulants. A few hours of separation has not been shown to prevent an added bleeding effect.
Evidence and practical considerations
Side effects & toxicity
An increased bleeding or GI-injury rate specifically from feverfew with meclofenamate has not been established.
- Exact scope
- Oral feverfew with oral meclofenamate sodium capsules. Exact formulation, dose and duration matter; other NSAIDs and other supplement preparations are not interchangeable. with Exact meclofenamate RxCUI 588003 IN; current RxNorm links precise ingredient meclofenamate sodium PIN 6677. Label capsules contain meclofenamic acid-equivalent doses as the sodium salt monohydrate and measure circulating meclofenamic acid. Evidence is explicitly limited to this oral sodium-salt product, not unrelated salts or mefenamic acid.
- Medication form and route
- Oral
What remains uncertain
- Available supplement-only and other-drug studies do not establish exact-pair clinical harm or exclude rare events. No validated preventive spacing interval.
Factors that may matter: Exact preparation and dose; Fasting versus fed dosing; Bleeding and ulcer history; Other medicines.
Read the supporting source summaries
Source 1: Current prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Prescription oral oral meclofenamate sodium capsules users; short human pharmacology studies where described.
One-week volunteer study showed little or no platelet aggregation or bleeding-time effect, unlike aspirin. Fecal blood loss was dose-related in isotope studies. Serious GI bleeding and ulcer warnings remain. Aluminum/magnesium antacids did not interfere with absorption.
How this applies: Exact current product label. Exact meclofenamate RxCUI 588003 IN; current RxNorm links precise ingredient meclofenamate sodium PIN 6677. Label capsules contain meclofenamic acid-equivalent doses as the sodium salt monohydrate and measure circulating meclofenamic acid. Evidence is explicitly limited to this oral sodium-salt product, not unrelated salts or mefenamic acid.
Short volunteer findings do not exclude clinical GI bleeding. Exact IN-to-sodium-PIN bridge is documented; no mefenamic acid or universal NSAID equivalence.
Source 2: Original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: One 36-year-old woman with migraine.
Vaginal bleeding and altered coagulation tests were associated with exposure; authors assessed a probable relationship.
How this applies: Indirect for oral meclofenamate sodium capsules co-use; exact preparation and endpoint retained.
Abstract-only, single case and no oral meclofenamate sodium capsules. Does not establish gastric ulcer injury, incidence, every dose or product equivalence.
Source 3: Medication terminology
rxnav.nlm.nih.gov · Source check Sep 10, 2026
Population: Terminology.
meclofenamate is IN. Related PIN 6677 is meclofenamate sodium.
How this applies: Exact identity.
Not clinical evidence.
Research assessment: · Open full citations ↗
Side effects & toxicity
Prolonged feverfew use warrants review in someone with bleeding risks.
- Exact scope
- Oral feverfew with oral meclofenamate sodium capsules. Exact formulation, dose and duration matter; other NSAIDs and other supplement preparations are not interchangeable. with Exact meclofenamate RxCUI 588003 IN; current RxNorm links precise ingredient meclofenamate sodium PIN 6677. Label capsules contain meclofenamic acid-equivalent doses as the sodium salt monohydrate and measure circulating meclofenamic acid. Evidence is explicitly limited to this oral sodium-salt product, not unrelated salts or mefenamic acid.
- Medication form and route
- Oral
What remains uncertain
- Precaution based on defined supplement evidence and the individual drug label; no exact combination event rate or universal discontinuation rule.
Factors that may matter: Exact preparation and dose; Fasting versus fed dosing; Bleeding and ulcer history; Other medicines.
Read the supporting source summaries
Source 1: Current prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Prescription oral oral meclofenamate sodium capsules users; short human pharmacology studies where described.
One-week volunteer study showed little or no platelet aggregation or bleeding-time effect, unlike aspirin. Fecal blood loss was dose-related in isotope studies. Serious GI bleeding and ulcer warnings remain. Aluminum/magnesium antacids did not interfere with absorption.
How this applies: Exact current product label. Exact meclofenamate RxCUI 588003 IN; current RxNorm links precise ingredient meclofenamate sodium PIN 6677. Label capsules contain meclofenamic acid-equivalent doses as the sodium salt monohydrate and measure circulating meclofenamic acid. Evidence is explicitly limited to this oral sodium-salt product, not unrelated salts or mefenamic acid.
Short volunteer findings do not exclude clinical GI bleeding. Exact IN-to-sodium-PIN bridge is documented; no mefenamic acid or universal NSAID equivalence.
Source 2: Original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: One 36-year-old woman with migraine.
Vaginal bleeding and altered coagulation tests were associated with exposure; authors assessed a probable relationship.
How this applies: Indirect for oral meclofenamate sodium capsules co-use; exact preparation and endpoint retained.
Abstract-only, single case and no oral meclofenamate sodium capsules. Does not establish gastric ulcer injury, incidence, every dose or product equivalence.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and article drafted. | |
| Research summary published |
Article revision: a2b2406a84ae886e
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.