The short answer
Confirm the valerian species before combining this root product with flurazepam. If it is Valeriana officinalis, added drowsiness is a reasonable concern; the generic name alone does not establish that identity.
What this answer covers
Generic root/rhizome name; species confirmation required.
- Supplement or preparation
- Radix et Rhizoma Valerianae
- Medication ingredient
- flurazepam
Flurazepam can impair next-day activities
A human repeated-dose study found impaired driving after flurazepam. The label describes an active metabolite that accumulates and persists, so the effects are not limited to the moment a capsule is taken.
What the supplement evidence adds
Guidance for Valeriana officinalis cautions about other sedating substances, but the current generic root name does not identify that species.
Preparations and endpoints differ
A different extract, dose or release formulation may behave differently. A study that fails to show sleep benefit does not prove that a product cannot impair alertness or add to a hypnotic’s effects.
Review co-use rather than choosing a gap
Discuss the product with the prescriber and avoid driving while impaired. No exact protective interval is established. Do not adjust flurazepam yourself; slow breathing or inability to wake requires emergency help.
Evidence and practical considerations
Timing & monitoring
Generic valerian root identity is unconfirmed; current claims cannot be validated with V.officinalis evidence. Narrower confirmed-species precaution retained.
- Exact scope
- Generic root/rhizome name; species confirmation required. with Flurazepam4501 IN; oral hydrochloride capsules and active desalkyl metabolite.
- Medication form and route
- oral medication; oral supplement
What remains uncertain
- No unmeasured pair incidence, blanket class transfer or arbitrary spacing interval.
Factors that may matter: Preparation; Dose; Other medicines; Organ function.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed flurazepam
Additive CNS-depressant effects; active desalkyl metabolite accumulates and may persist for days.
How this applies: Exact flurazepam RxCUI 4501 IN, with stated salt/formulation/route bridge.
No named St John’s wort clinical interaction or universal botanical dose rule.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Participants in a repeated-dose driving study.
Residual driving impairment with flurazepam, including later next-day testing; stronger morning effect.
How this applies: Not a supplement-combination trial; dose and study population do not give exact-pair risk.
Not a supplement-combination trial; dose and study population do not give exact-pair risk.
Source 3: federal supplement safety guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: Users of the specified supplement.
Possible but unproven sleep-inducing effects; advises against combining valerian with alcohol or sedatives.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 4: federal botanical identity and safety guidance
ods.od.nih.gov · Source check Sep 10, 2026
Population: Users of Valeriana officinalis.
The fact sheet covers only V. officinalis among more than 250 valerian species; possible additive sedation is theoretical.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 5: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 391 participants with anxiety and insomnia.
Neither botanical improved its primary anxiety/insomnia outcome over placebo.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Research assessment: · Open full citations ↗
Side effects & toxicity
Generic valerian root identity is unconfirmed; current claims cannot be validated with V.officinalis evidence. Narrower confirmed-species precaution retained.
- Exact scope
- Generic root/rhizome name; species confirmation required. with Flurazepam4501 IN; oral hydrochloride capsules and active desalkyl metabolite.
- Medication form and route
- oral medication; oral supplement
What remains uncertain
- No unmeasured pair incidence, blanket class transfer or arbitrary spacing interval.
Factors that may matter: Preparation; Dose; Other medicines; Organ function.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed flurazepam
Additive CNS-depressant effects; active desalkyl metabolite accumulates and may persist for days.
How this applies: Exact flurazepam RxCUI 4501 IN, with stated salt/formulation/route bridge.
No named St John’s wort clinical interaction or universal botanical dose rule.
Source 2: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Participants in a repeated-dose driving study.
Residual driving impairment with flurazepam, including later next-day testing; stronger morning effect.
How this applies: Not a supplement-combination trial; dose and study population do not give exact-pair risk.
Not a supplement-combination trial; dose and study population do not give exact-pair risk.
Source 3: federal supplement safety guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: Users of the specified supplement.
Possible but unproven sleep-inducing effects; advises against combining valerian with alcohol or sedatives.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 4: federal botanical identity and safety guidance
ods.od.nih.gov · Source check Sep 10, 2026
Population: Users of Valeriana officinalis.
The fact sheet covers only V. officinalis among more than 250 valerian species; possible additive sedation is theoretical.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 5: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 391 participants with anxiety and insomnia.
Neither botanical improved its primary anxiety/insomnia outcome over placebo.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Research assessment: · Open full citations ↗
Side effects & toxicity
If confirmed as Valeriana officinalis, additive drowsiness with flurazepam is a conditional concern.
- Exact scope
- Confirmed Valeriana officinalis root product. with Flurazepam oral hydrochloride with long-lived active metabolite.
- Medication form and route
- oral medication; oral supplement
What remains uncertain
- No exact-pair incidence or protective gap.
Factors that may matter: Species; Dose; Other sedatives.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed flurazepam
Additive CNS-depressant effects; active desalkyl metabolite accumulates and may persist for days.
How this applies: Exact flurazepam RxCUI 4501 IN, with stated salt/formulation/route bridge.
No named St John’s wort clinical interaction or universal botanical dose rule.
Source 2: federal supplement safety guidance
nccih.nih.gov · Source check Sep 10, 2026
Population: Users of the specified supplement.
Possible but unproven sleep-inducing effects; advises against combining valerian with alcohol or sedatives.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 3: federal botanical identity and safety guidance
ods.od.nih.gov · Source check Sep 10, 2026
Population: Users of Valeriana officinalis.
The fact sheet covers only V. officinalis among more than 250 valerian species; possible additive sedation is theoretical.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Source 4: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 391 participants with anxiety and insomnia.
Neither botanical improved its primary anxiety/insomnia outcome over placebo.
How this applies: Original source interpreted for flurazepam only within the stated preparation and endpoint limits.
Not a direct flurazepam combination trial; original preparation, dose and endpoint limits apply. No exact-pair adverse-event rate or protective spacing established.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Prepared exact flurazepam article with formulation-specific evidence and uncertainty. |
Article revision: 424034f34128fb04
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.