The short answer
Olive leaf extract could add to blood-pressure lowering from enalapril, but the size and clinical importance of that effect are not established for this exact combination. Some extract trials lowered pressure and another did not. Discuss the product before starting it, particularly if your pressure is already low or you feel dizzy.
What this answer covers
Oral Olea europaea leaf extracts with oral enalapril. This does not describe olive oil as food, olive fruit, or every product with an olive-derived ingredient.
- Supplement or preparation
- olive leaf extract
- Medication ingredient
- enalapril
Why is an additional effect plausible?
One trial of a defined olive leaf extract found a modest reduction in 24-hour blood pressure compared with control. However, that study excluded people taking blood-pressure medicines. Combining that finding with enalapril’s effect suggests a potential concern; it does not directly show an increased rate of harmful low pressure during co-use.
Was olive leaf tested together with an ACE inhibitor?
A frequently cited trial compared olive leaf extract with captopril in separate groups. It did not give both treatments together, and captopril is not enalapril. A comparison between two treatments cannot establish what happens when they are combined or justify replacing a prescribed medicine with the extract.
Do all products have the same effect?
No uniform response is established. A separate placebo-controlled trial in overweight or obese adults with mildly elevated cholesterol found no significant blood-pressure difference after eight weeks. The products, doses and participants differed from positive studies. Keep those limits in mind when reading a broad warning about olive leaf.
What is a practical next step?
Have a pharmacist or prescriber review the label, dose and complete medicine list. Existing lightheadedness, dehydration, heart failure or intensive diuretic treatment deserve particular attention because they can increase enalapril-related hypotension risk. The inspected sources do not establish that taking the extract a few hours later prevents an additional effect.
Evidence and practical considerations
Physiologic interactions
An additional blood-pressure effect is plausible from olive-leaf-only studies, but evidence is insufficient to establish symptomatic hypotension from olive leaf extract plus enalapril. The captopril comparison is not a combination study.
- Exact scope
- Oral Olea europaea leaf extracts with oral enalapril. This does not describe olive oil as food, olive fruit, or every product with an olive-derived ingredient. with Enalapril, RxCUI 3827, IN. Oral enalapril maleate tablets are an explicitly identified salt formulation of enalapril in the label. This bridge applies to the labeled oral prodrug; injected enalaprilat, other ACE inhibitors and combination products are not assigned this evidence automatically.
- Medication form and route
- oral
What remains uncertain
- No exact enalapril co-use trial was identified. Results vary across extract regimens and populations. A measured average reduction is different from a documented adverse hypotension event; a neutral trial does not establish safety.
Factors that may matter: extract composition; baseline blood pressure; fluid or salt depletion; concurrent diuretics.
Read the supporting source summaries
Source 1: original clinical research
link.springer.com · Source check Sep 10, 2026
Population: Prehypertensive men; 61 enrolled in the full methods, with 60 described in the abstract. Antihypertensive medication use was excluded.
Mean 24-hour systolic and diastolic pressure were lower by 3.33 and 2.42 mm Hg, respectively, relative to control.
How this applies: Direct evidence for this extract affecting blood pressure alone, used only as indirect support for a possible additive effect with enalapril.
No concurrent enalapril or other blood-pressure medicine. Does not quantify symptomatic hypotension from co-use.
Source 2: original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients with stage-1 hypertension.
Pressure fell from baseline in both groups, without a significant between-group difference in the reductions.
How this applies: Supports distinguishing an olive-leaf-versus-drug trial from an interaction trial.
A comparator study, not coadministration. Captopril is a different ingredient from enalapril. Similar measured changes do not establish interchangeability.
Source 3: original clinical research
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 77 overweight or obese adults with mildly elevated cholesterol; 74 completed the study.
No significant between-group difference in blood pressure was detected.
How this applies: Retains the neutral result rather than assuming every olive leaf product lowers blood pressure.
Different population and regimen from positive olive-leaf trials. No exact enalapril co-use analysis is given in the abstract.
Source 4: regulatory prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral enalapril maleate for hypertension or heart failure.
Excessive hypotension is uncommon in uncomplicated hypertension but is a recognized risk, especially with heart failure or salt or fluid depletion. Patients should report lightheadedness and conditions causing dehydration.
How this applies: The maleate formulation is explicitly identified as a salt of enalapril. Applies to oral enalapril, RxCUI 3827 IN; does not transfer to injected enalaprilat or another ACE inhibitor.
Provides the exact medication context. It does not establish an interaction with any of the supplements assessed in this batch or a dose-separation rule.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Sources checked and original article drafted. Exact medicine, preparation and study limits are recorded for review. | |
| Research summary published |
Article revision: 644ef3c578011d19
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.