Can I take Folic Acid with Methotrexate?
Applies to clinician-directed folic acid with low-dose weekly systemic methotrexate for inflammatory disease; folinic acid and rescue protocols are separate.
Read the interaction guide →Medication overview
Methotrexate: Supplement Interactions
Find the available answers about methotrexate and supplements. Each guide explains its evidence and the forms it covers.
Supplement combinations
1 published guides. Coverage is limited to the combinations listed.
A supplement missing from this list has not been cleared for use with the medication. These pages do not assess every product, formulation, or combination.
Publication status, clinical review and change history are shown in each interaction guide.