Can I take St. John's Wort with Estradiol?
Route matters: transdermal estradiol may be less affected than oral estradiol, but the difference is not quantified.
Read the interaction guide →Medication overview
Estradiol: Supplement Interactions
Find the available answers about estradiol and supplements. Each guide explains its evidence and the forms it covers.
Supplement combinations
1 published guides. Coverage is limited to the combinations listed.
A supplement missing from this list has not been cleared for use with the medication. These pages do not assess every product, formulation, or combination.
Publication status, clinical review and change history are shown in each interaction guide.