The short answer
Yerba mate contains caffeine, so review the product and total caffeine intake with your pharmacist during methamphetamine treatment. The exact pair has not been shown to cause QT prolongation, arrhythmia or increased blood pressure.
What this answer covers
Ilex paraguariensis leaf tea or supplements; the inspected tea trial does not define concentrated extract exposure.
- Supplement or preparation
- Ilex paraguariensis
- Medication ingredient
- methamphetamine
Caffeine content is product-specific
The inspected yerba mate tea provided a measured amount of caffeine. A concentrated extract or mixed energy product may give a different amount, so use the actual label rather than assuming equivalence to a cup of tea.
The tea trial did not show raised pressure
An eight-week controlled trial found lower blood pressure with the studied mate tea. Prescription drug users were excluded, so this does not establish safety with methamphetamine.
Heart-rhythm claims remain unproven
The sources do not establish a QT or arrhythmia interaction for this exact pair. Methamphetamine can still raise pulse and blood pressure, and caffeine sensitivity varies. Review new symptoms and do not rely on a spacing interval as protection.
Symptoms that need attention
Seek urgent medical care for chest pain, shortness of breath or fainting while taking methamphetamine. Tell your prescriber about new palpitations, troublesome stimulation or sleep disruption, and let the treating team decide on medication changes.
Evidence and practical considerations
Side effects & toxicity
Caffeine content supports individualized review, while the broad exact-pair cardiovascular claim remains unproven.
- Exact scope
- Ilex paraguariensis leaf tea or supplements; the inspected tea trial does not define concentrated extract exposure. with Prescribed oral S-methamphetamine hydrochloride; RxNorm 6816 IN and label section 11 establish active-moiety relationship, not dose or stereoisomer interchangeability.
- Medication form and route
- oral
- Timing or duration
- Dose, pattern of use and preparation matter; no universal protective spacing interval established.
What remains uncertain
- The original mate trial excluded prescription drug users and found lower pressure; no methamphetamine co-use assessment.
Factors that may matter: exact product; other medicines; prescribed dose; baseline cardiovascular or serotonergic risk.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed oral methamphetamine hydrochloride tablets.
Sections 2.4 and 7.1 identify acidifying agents such as ascorbic acid as lowering levels and alkalinizing agents such as sodium bicarbonate as increasing levels; avoid gastrointestinal and urinary alkalinizing co-use. Sections 5.8 and 7.1 warn about serotonin syndrome with serotonergic agents, specifically including tryptophan and St Johns wort. Section 5.3 calls for blood-pressure and pulse monitoring.
How this applies: RxNorm 6816 IN maps to this SPL, and description confirms active ingredient salt relationship. Applies to prescribed oral S-methamphetamine hydrochloride, not other stimulants or unapproved routes.
Regulatory guidance is not a quantified trial for every named pair. No one-hour supplement spacing instruction. General amphetamine language is explicitly incorporated in this exact methamphetamine product label.
Source 2: original clinical study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: 52 completers, healthy or hypercholesterolemic nonhabitual consumers.
Blood pressure decreased during mate use.
How this applies: Supports only the specific result and preparation described; applicability to prescribed oral methamphetamine is explicitly limited.
Prescription drug users were excluded. Conducted 2012-2013, registered retrospectively and published 2025. Tea is not every concentrated extract; no methamphetamine safety inference.
Source 3: official consumer guidance
fda.gov · Source check Sep 10, 2026
Population: Caffeine consumers, including adults and children.
Too much caffeine can cause palpitations, increased heart rate, anxiety and sleep problems. Sensitivity varies; medicines and health conditions can matter.
How this applies: Supports reviewing total caffeine and individual susceptibility without claiming every amount is unsafe.
General caffeine guidance is not a methamphetamine-specific safe intake limit.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current available claims adjudicated from inspected sources; no clinical review asserted. | |
| Research summary published |
Article revision: 4892afde41eef895
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.