The short answer
Hyoscine, also called scopolamine, can add to dicyclomine’s anticholinergic effects. The reviewed evidence supports an effects-based precaution, not a demonstrated rise in dicyclomine blood levels.
What this answer covers
Oral dicyclomine with the specific preparation described below.
- Supplement or preparation
- Hyoscine
- Medication ingredient
- dicyclomine
Two medicines can add similar effects
Both dicyclomine and scopolamine block muscarinic signaling. Their labels warn about combinations with other anticholinergic agents, including increased confusion, constipation, urinary difficulty and other adverse effects.
Confirm which hyoscine product you mean
The source inspected here concerns a scopolamine skin patch. Hyoscine butylbromide is a different ingredient and should not be silently substituted. A generic name in the supplement list does not establish the route or dose you are actually using.
This is not a measured metabolism interaction
The sources do not show that scopolamine raises dicyclomine concentrations. Added effects can occur without a change in blood levels, so a pharmacodynamic precaution should not be described as proven increased absorption or impaired clearance.
Review the combined anticholinergic burden
Have your pharmacist check both products and any other medicines with similar effects. Follow the prescribed regimen while arranging that review; there is no established short dosing gap that removes the overlap in effects.
Evidence and practical considerations
Side effects & toxicity
Hyoscine, also called scopolamine, can add to dicyclomine’s anticholinergic effects. The reviewed evidence supports an effects-based precaution, not a demonstrated rise in dicyclomine blood levels.
- Exact scope
- Oral dicyclomine with the specific preparation described below. with Oral dicyclomine; the hyoscine source, where relevant, is explicitly transdermal.
- Medication form and route
- oral
What remains uncertain
- Conditional pharmacodynamic anticholinergic burden supported by exact dicyclomine and transdermal scopolamine labels. Original elevated-level/toxicity wording is insufficient as a blood-level claim; hyoscine butylbromide is excluded.
Factors that may matter: Exact preparation and amount; Other medicines with overlapping effects; Route and gut-transit status where relevant.
Read the supporting source summaries
Source 1: Current U.S. regulatory product labeling
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral dicyclomine.
Dicyclomine reduces gastrointestinal motility through antimuscarinic effects and can cause dizziness or drowsiness. Other anticholinergic agents may increase actions and adverse effects. Metabolism has not been studied.
How this applies: Exact active ingredient and oral-route context.
Label warnings do not measure every exact supplement pair or provide a universal safe supplement dose or interval.
Source 2: Current U.S. regulatory product labeling
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed transdermal scopolamine.
Other anticholinergic agents can increase CNS adverse effects, intestinal obstruction and urinary retention.
How this applies: Conditional pharmacodynamic interaction with another anticholinergic medicine.
Route-specific label; not proof of increased dicyclomine blood levels or every hyoscine product.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Initial source-checked research draft with exact preparation limits, contrary findings and source-access details. Clinical review not recorded. | |
| Research summary published |
Article revision: 197617dbf394fea4
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.