The short answer
Review ginkgo with the prescriber before taking it with clorazepate, especially when clorazepate is used for seizures. The leaf monograph warns about possible further seizures in people with epilepsy.
What this answer covers
Ginkgo biloba leaf medicinal preparations; seed-toxin reports do not establish the effect of every leaf extract.
- Supplement or preparation
- Ginkgo biloba
- Medication ingredient
- clorazepate
The reason you take clorazepate matters
Clorazepate can be prescribed for anxiety, acute alcohol withdrawal or as additional treatment for partial seizures. A ginkgo precaution about epilepsy is particularly relevant to the last group.
What the leaf monograph warns
The European ginkgo leaf monograph states that further seizures in people with epilepsy cannot be excluded. This is a precaution for specified leaf preparations, without needing to equate leaf products with ginkgo seeds.
An interaction mechanism is not established
The source does not measure clorazepate or its active metabolite during ginkgo use. It cannot show that ginkgo lowers drug levels or that separating doses prevents seizures.
Keep seizure treatment supervised
Ask the prescriber before adding ginkgo and seek prompt advice if seizures change. Do not abruptly stop clorazepate; withdrawal itself can be dangerous.
Evidence and practical considerations
Side effects & toxicity
Conditional review is supported by the leaf-specific epilepsy precaution and clorazepate’s seizure indication, not a proven exact drug interaction.
- Exact scope
- Ginkgo biloba leaf medicinal preparations; seed-toxin reports do not establish the effect of every leaf extract. with Exact oral clorazepate dipotassium tablets. Rapid oral decarboxylation forms nordiazepam, with essentially no circulating parent; nordiazepam half-life about 40-50 hours. Human-serum-albumin binding of the swallowed parent is not an in vivo metabolite study. RxNorm IN 2353 relates to PIN 2607 dipotassium, matching the label.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact co-use trial, quantified risk or validated spacing rule. Epilepsy precaution should not be described as measured reduced clorazepate exposure.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral clorazepate.
Can impair alertness and coordination; other CNS depressants can increase impairment. Opioid combinations have a specific respiratory-depression warning. Dependence and withdrawal require supervised changes. Rapid oral decarboxylation forms nordiazepam, with essentially no circulating parent; nordiazepam half-life about 40-50 hours. Human-serum-albumin binding of the swallowed parent is not an in vivo metabolite study. RxNorm IN 2353 relates to PIN 2607 dipotassium, matching the label.
How this applies: Exact IN and labeled oral formulation; route, salt and metabolite distinctions retained.
No quantified risk for every herb or universal protective spacing interval. Opioid-specific evidence does not prove equal botanical respiratory risk.
Source 2: EMA herbal monograph or public assessment summary
ema.europa.eu · Source check Sep 10, 2026
Population: People considering the specified herbal medicinal preparations.
In people with epilepsy, further seizures promoted by ginkgo preparations cannot be excluded.
How this applies: Leaf-specific epilepsy caution independent of extrapolation from ginkgo seed toxin.
Precaution, not a clorazepate interaction trial or quantified seizure frequency.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. | |
| Research summary published |
Article revision: 03560029ef0c714a
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.