The short answer
In small, short studies of healthy men using continuous nitroglycerin patches, folic acid 10 mg/day helped preserve measured vascular responses, while 1 mg/day did not. These experimental findings do not establish a clinical benefit or justify routine use; high doses can mask vitamin B12 deficiency.
What this answer covers
Evidence concerns continuous transdermal nitroglycerin with oral folic acid for about one week in small healthy-male study groups.
- Supplement or preparation
- Folic acid
- Medication ingredient
- nitroglycerin
Evidence and practical considerations
Absorption & effectiveness
Exact human studies disagree by dose, so the correct conclusion is dose-dependent conflicting evidence rather than a universal interaction.
- Exact scope
- folic acid supplement with nitroglycerin
- Medication form and route
- continuous transdermal nitroglycerin with oral folic acid in healthy male study populations
- Timing or duration
- Studied for approximately one week; 10 mg/day showed benefit and 1 mg/day did not.
What remains uncertain
- The effect changes with dose: 10 mg/day was positive, 1 mg/day negative.
- High-dose folic acid can mask vitamin B12 deficiency and is not a routine nitroglycerin recommendation.
Factors that may matter: folic acid dose; vitamin B12 status; continuous nitrate exposure; healthy-volunteer population.
Read the supporting source summaries
Source 1: randomized double-blind human study
pmc.ncbi.nlm.nih.gov · Source check Jul 25, 2026
Population: Twenty healthy male nonsmokers.
One milligram per day did not prevent dysfunction or tolerance; the paper contrasts an earlier positive 10 mg/day study.
Small healthy-male study and surrogate outcomes.
Source 2: randomized human clinical study
pubmed.ncbi.nlm.nih.gov · Source check Jul 25, 2026
Population: Eighteen healthy male volunteers.
Ten milligrams per day prevented the studied dysfunction and tolerance.
Small, high-dose, healthy-volunteer, surrogate-outcome study.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Research summary published |
Article revision: c0cdb71628b218cd
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
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