The short answer
Avoid self-starting Scotch broom with phenelzine. Cytisus scoparius can contain tyramine, and phenelzine makes high-tyramine exposures hazardous. The concern is based on the plant's chemistry and the medication warning; a direct clinical trial of this pair was not identified.
What this answer covers
Oral Cytisus scoparius preparations that contain tyramine, particularly the aerial or flowering material described in the source. Plant part and preparation are essential; other broom species and purified constituents are not interchangeable.
- Supplement or preparation
- Cytisus scoparius
- Medication ingredient
- phenelzine
The concern is tyramine content
Phenelzine inhibits the pathway that normally handles tyramine. A tyramine-containing plant preparation can therefore raise a concern even though it is sold as a herb. This does not mean the tyramine content of every broom product is known.
Plant part changes the assessment
The original chemistry study found different constituents across aerial material, flowers and seeds. A species name alone cannot establish the content of an extract. Broom preparations should not be merged with other plants that share a common name.
What has and has not been demonstrated
The chemical finding and phenelzine warning support a precaution. They are not a clinical observation of a person taking this exact product with phenelzine, and they do not supply a safe amount.
Do not rely on separating the doses
No protective spacing schedule was identified. Discuss any proposed use with the prescriber rather than altering phenelzine yourself. Sudden severe headache, chest pain or marked blood-pressure symptoms require urgent care.
Evidence and practical considerations
Side effects & toxicity
Original phytochemical research identified tyramine in Cytisus scoparius and variation between plant parts. NARDIL warns against high-tyramine exposures. The exact botanical-pair conclusion is a constituent-based inference.
- Exact scope
- Oral Cytisus scoparius preparations that contain tyramine, particularly the aerial or flowering material described in the source. Plant part and preparation are essential; other broom species and purified constituents are not interchangeable. with Oral phenelzine tablets; current sulfate-tablet labeling uses the named active ingredient.
- Medication form and route
- oral
What remains uncertain
- The inspected chemical abstract does not quantify tyramine in a current supplement. No human exact-pair dose-response study or verified clinical case was identified.
Factors that may matter: Exact supplement preparation and complete concomitant-medication list require assessment..
Read the supporting source summaries
Source 1: Current U.S. prescribing information
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral phenelzine sulfate tablets.
The label prohibits sympathomimetics, L-tryptophan, L-tyrosine, phenylalanine and serotonergic agents. It warns about excessive caffeine and high-tyramine exposures.
How this applies: Primary authority for phenelzine oral-tablet precautions; each article identifies whether the supplement is named or the application is a constituent/class inference.
Regulatory instructions do not quantify an exact-pair event rate or validate every botanical formulation.
Source 2: Original phytochemical study
sciencedirect.com · Source check Sep 10, 2026
Population: Plant samples, not human participants.
Tyramine was isolated with alkaloids; composition varied considerably between the examined plant parts.
How this applies: Constituent evidence for a conditional tyramine-based concern; not a statement that every broom preparation has the same amount.
Full paper inaccessible in this session. The abstract supplies neither a clinical dose nor a tested phenelzine interaction.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Initial targeted research draft. Inspected source material, adjudicated the current checker statements, and recorded preparation limits. Clinical review has not occurred. | |
| Research summary published |
Article revision: 906372ef2f8d8107
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.