The short answer
Avoid grapefruit juice while taking cariprazine, as directed by the UK capsule label. Ask the pharmacist about other grapefruit products; an exact toxicity rate is not known.
What this answer covers
Citrus paradisi: explicit advice concerns grapefruit juice, not every extract, peel or flesh preparation.
- Supplement or preparation
- Citrus paradisi
- Medication ingredient
- cariprazine
The product label names the juice
The UK cariprazine capsule label advises avoiding grapefruit juice. Review the exact grapefruit preparation rather than assuming every extract has the same exposure.
Clinical metabolism evidence used an antibiotic
A patient study found higher total cariprazine exposure with erythromycin. This supports the relevance of CYP3A4, but does not measure the effect of grapefruit.
Long-lived metabolites make timing important
Cariprazine has active metabolites that persist, and changes may take weeks to be fully reflected. A short gap between juice and the medicine is not established protection.
Keep dose decisions with the prescriber
Bring your food and supplement list for review. Do not lower or skip cariprazine to compensate for an assumed grapefruit effect.
Evidence and practical considerations
Side effects & toxicity
Conditional elevated-exposure concern follows exact label guidance and demonstrated CYP3A4 sensitivity, without a direct grapefruit effect size.
- Exact scope
- Citrus paradisi: explicit advice concerns grapefruit juice, not every extract, peel or flesh preparation. with Exact cariprazine hydrochloride capsules. Exact RxNorm IN1667655; hydrochloride oral capsules. Active DCAR and DDCAR metabolites and long equilibration matter.
- Medication form and route
- oral
- Timing or duration
- Source-specific single-dose, repeated-dose and observational exposures distinguished.
What remains uncertain
- No exact grapefruit trial identified. Antibiotic inhibition and model predictions cannot quantify juice or retail extract effects.
Factors that may matter: preparation and plant part; clinical indication; dose; other medicines; baseline alertness.
Read the supporting source summaries
Source 1: current product label
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: People prescribed cariprazine.
Somnolence/falls precautions; CYP3A4 inhibitors raise exposure, inducer net effect unstudied and unclear; long-lived active metabolites.
How this applies: Exact RxNorm IN1667655; hydrochloride oral capsules. Active DCAR and DDCAR metabolites and long equilibration matter.
No supplement-specific event rate, universal timing rule or untested route/preparation equivalence.
Source 2: official product label
medicines.org.uk · Source check Sep 10, 2026
Population: People prescribed oral cariprazine hydrochloride capsules.
Advises avoiding grapefruit juice; contraindicates strong/moderate CYP3A4 inducers including St John’s wort.
How this applies: Exact oral ingredient guidance with geographic and evidence boundaries.
UK labeling differs from US inhibitor instructions. No direct grapefruit trial or measured herb interaction; US label says inducer net effect remains unclear.
Source 3: original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: Forty-two male patients with schizophrenia.
Total parent-plus-active-metabolite exposure rose about 40–50%; CYP2D6 phenotype had no substantial effect.
How this applies: Only the named drug, preparation, route and measured endpoints apply.
Erythromycin, not grapefruit. Open-label fixed-sequence study; measured and model-predicted effects must be distinguished.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Research summary published | |
| Article prepared | |
| Current exact available claims adjudicated using original captures and explicit identity and comparator limits. |
Article revision: 6a22766fd2dccc9f
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
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Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.