The short answer
A borage-oil interaction with thiothixene has not been established. One original seizure report involved borage oil without thiothixene and had unresolved product and co-supplement factors.
What this answer covers
Oral thiothixene with the exact supplement preparation described.
- Supplement or preparation
- Borage Oil
- Medication ingredient
- thiothixene
The original case did not involve thiothixene
A woman developed status epilepticus after reporting about a week of borage-oil use. She also used several other supplements, and no prescription-drug regimen was reported. The case therefore does not demonstrate this exact combination.
The product could not be fully checked
Gamma-linolenic acid was elevated, but the original bottle was unavailable. The authors could not resolve the precise composition or exclude alternative explanations. This prevents turning the event into a predictable risk for every borage oil product.
The medicine’s own seizure warning is separate
Thiothixene labeling describes infrequent seizures and cautions in susceptible patients. That makes a seizure history relevant to a supplement review, but it does not establish that borage oil adds to the risk or identify a safe amount.
Discuss use before changing the regimen
Show the complete oil label and other supplements to the prescriber, particularly with epilepsy or prior unexplained seizures. Do not assume an hours-apart schedule prevents the concern or change thiothixene on the basis of this single report.
Evidence and practical considerations
Side effects & toxicity
A borage-oil interaction with thiothixene has not been established. One original seizure report involved borage oil without thiothixene and had unresolved product and co-supplement factors.
- Exact scope
- Oral thiothixene with the exact supplement preparation described. with Oral thiothixene with the stated label and formulation limits.
- Medication form and route
- oral
What remains uncertain
- The single original case did not report thiothixene or other prescription use. Other supplements and unavailable product testing complicate causality. Thiothixene has a separate seizure precaution, supporting review, but the exact combination claim remains insufficiently supported.
Factors that may matter: Exact preparation and amount; Other medicines; Seizure history, alertness or electrolyte status where relevant.
Read the supporting source summaries
Source 1: Current U.S. regulatory product labeling
dailymed.nlm.nih.gov · Source check Sep 10, 2026
Population: Patients prescribed oral thiothixene.
Mild drowsiness can occur and often subsides. CNS depressants may add effects, including hypotension. Seizures occur infrequently; anticholinergic and photosensitivity precautions are described.
How this applies: Exact ingredient and oral-route clinical context.
Label class warnings do not establish every exact botanical interaction, event rate or protective supplement interval.
Source 2: Original human study
pubmed.ncbi.nlm.nih.gov · Source check Sep 10, 2026
Population: One woman without a reported prescription-drug regimen.
Status epilepticus occurred; gamma-linolenic acid was elevated. The original bottle was unavailable, so product composition and alternative explanations were unresolved.
How this applies: The original report is a supplement-associated signal, not an exact antipsychotic combination study.
No thiothixene exposure. One confounded case cannot establish a causal oil interaction or a predictable safe dose.
Research assessment: · Open full citations ↗
Review and change history
- Publication status
- Published research summary
- Clinical review
- Not yet recorded
| Date | Update |
|---|---|
| Article prepared | |
| Initial source-checked draft with exact preparation limits, original study findings and uncertainty. Clinical review not recorded. | |
| Research summary published |
Article revision: 2c86e7caa9a05677
This guide brings together the evidence records used by our interaction checker. Each finding retains its own preparation limits, research date, and source summaries.
Full citations require verification. Reading this answer and the source summaries does not.
Taking other supplements or medications?
Use the checker to explore your other combinations. Ask a pharmacist to review the exact products, amounts and medical conditions in your complete list.
Open the interaction checkerInformation, not medical advice. Do not change prescribed treatment based on this guide.